A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy

Lanlan Zhang,1 Chengzhong Wang,1 Wei Li2 1Department of Pediatric Neurology, Yancheng Maternal and Child Health Hospital, 2Department of Medical Imaging, Jiangsu Vocational College of Medicine, Yancheng, China Objective: To evaluate clinical efficacy, safety, and tolerability of levetiracetam as m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang LL, Wang CZ, Li W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	levetiracetam epilepsy children meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e2d33b92b3034cb087f3418e19000905
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e2d33b92b3034cb087f3418e19000905
record_format	dspace
spelling	oai:doaj.org-article:e2d33b92b3034cb087f3418e190009052021-12-02T02:31:49ZA meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy1178-2021https://doaj.org/article/e2d33b92b3034cb087f3418e190009052018-03-01T00:00:00Zhttps://www.dovepress.com/a-meta-analysis-of-randomized-controlled-trials-on-levetiracetam-in-th-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lanlan Zhang,1 Chengzhong Wang,1 Wei Li2 1Department of Pediatric Neurology, Yancheng Maternal and Child Health Hospital, 2Department of Medical Imaging, Jiangsu Vocational College of Medicine, Yancheng, China Objective: To evaluate clinical efficacy, safety, and tolerability of levetiracetam as mono- or adjunctive therapy in the treatment of children and adolescents with epilepsy.Materials and methods: We performed a meta-analysis of randomized controlled trials published from January 2007 to December 2016 in the databases Web of Science, Medline, Embase, Cochrane Library, and PubMed, Bing, Baidu, Google Scholar, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data. All of the studies eligible were compared for the efficacy, safety, and tolerability of levetiracetam with other antiepileptic drugs (AEDs) in epilepsy.Results: Thirteen randomized controlled trials on a total of 1,013 patients met the inclusion criteria in present study. Compared with other AEDs (oxcarbazepine, valproate, sulthiame, carbamazepine, and placebo), we found that levetiracetam had a comparable seizure-free rate (RR 1.16, 95% CI 1.03–1.31; P=0.30). Regarding seizure-frequency reduction ≥50% from baseline, levetiracetam also seemed equivalent to other AEDs (RR 1.08, 95% CI 1.01–1.16; P=0.35). In spite of patients treated with levetiracetam having a lower incidence of side effects compared with patients treated with other AEDs (RR 0.90, 95% CI 0.77–1.06), the difference between them was minute and not statistically significant (P=0.22).Conclusion: Based on this meta-analysis, it seemed that levetiracetam had comparable effects concerning efficacy, tolerability, and adverse events. Nevertheless, 13 studies were insufficient to draw a conclusion that levetiracetam is effective as mono- and adjunctive therapy for all types of epilepsy syndromes and seizures. Larger-sample and more well-designed trials are needed to justify the widespread use of levetiracetam in the treatment of children and adolescents. Keywords: levetiracetam, epilepsy, children, antiepileptic drug, RCT, efficacyZhang LLWang CZLi WDove Medical Pressarticlelevetiracetamepilepsychildrenmeta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 769-779 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	levetiracetam epilepsy children meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	levetiracetam epilepsy children meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhang LL Wang CZ Li W A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy
description	Lanlan Zhang,1 Chengzhong Wang,1 Wei Li2 1Department of Pediatric Neurology, Yancheng Maternal and Child Health Hospital, 2Department of Medical Imaging, Jiangsu Vocational College of Medicine, Yancheng, China Objective: To evaluate clinical efficacy, safety, and tolerability of levetiracetam as mono- or adjunctive therapy in the treatment of children and adolescents with epilepsy.Materials and methods: We performed a meta-analysis of randomized controlled trials published from January 2007 to December 2016 in the databases Web of Science, Medline, Embase, Cochrane Library, and PubMed, Bing, Baidu, Google Scholar, Chinese National Knowledge Infrastructure (CNKI), and Wanfang Data. All of the studies eligible were compared for the efficacy, safety, and tolerability of levetiracetam with other antiepileptic drugs (AEDs) in epilepsy.Results: Thirteen randomized controlled trials on a total of 1,013 patients met the inclusion criteria in present study. Compared with other AEDs (oxcarbazepine, valproate, sulthiame, carbamazepine, and placebo), we found that levetiracetam had a comparable seizure-free rate (RR 1.16, 95% CI 1.03–1.31; P=0.30). Regarding seizure-frequency reduction ≥50% from baseline, levetiracetam also seemed equivalent to other AEDs (RR 1.08, 95% CI 1.01–1.16; P=0.35). In spite of patients treated with levetiracetam having a lower incidence of side effects compared with patients treated with other AEDs (RR 0.90, 95% CI 0.77–1.06), the difference between them was minute and not statistically significant (P=0.22).Conclusion: Based on this meta-analysis, it seemed that levetiracetam had comparable effects concerning efficacy, tolerability, and adverse events. Nevertheless, 13 studies were insufficient to draw a conclusion that levetiracetam is effective as mono- and adjunctive therapy for all types of epilepsy syndromes and seizures. Larger-sample and more well-designed trials are needed to justify the widespread use of levetiracetam in the treatment of children and adolescents. Keywords: levetiracetam, epilepsy, children, antiepileptic drug, RCT, efficacy
format	article
author	Zhang LL Wang CZ Li W
author_facet	Zhang LL Wang CZ Li W
author_sort	Zhang LL
title	A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy
title_short	A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy
title_full	A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy
title_fullStr	A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy
title_full_unstemmed	A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy
title_sort	meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e2d33b92b3034cb087f3418e19000905
work_keys_str_mv	AT zhangll ametaanalysisofrandomizedcontrolledtrialsonlevetiracetaminthetreatmentofpediatricpatientswithepilepsy AT wangcz ametaanalysisofrandomizedcontrolledtrialsonlevetiracetaminthetreatmentofpediatricpatientswithepilepsy AT liw ametaanalysisofrandomizedcontrolledtrialsonlevetiracetaminthetreatmentofpediatricpatientswithepilepsy AT zhangll metaanalysisofrandomizedcontrolledtrialsonlevetiracetaminthetreatmentofpediatricpatientswithepilepsy AT wangcz metaanalysisofrandomizedcontrolledtrialsonlevetiracetaminthetreatmentofpediatricpatientswithepilepsy AT liw metaanalysisofrandomizedcontrolledtrialsonlevetiracetaminthetreatmentofpediatricpatientswithepilepsy
_version_	1718402444379029504

A meta-analysis of randomized controlled trials on levetiracetam in the treatment of pediatric patients with epilepsy

Ejemplares similares