Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 polarization and associated type 2 immune responses.

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Autores principales:	Zhipeng Xu, Lei Xu, Wei Li, Xin Jin, Xian Song, Xiaojun Chen, Jifeng Zhu, Sha Zhou, Yong Li, Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen, Chuan Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2d3db65188b4e788f0584c13918017c
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spelling	oai:doaj.org-article:e2d3db65188b4e788f0584c13918017c2021-12-02T14:41:22ZInnate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection10.1038/ncomms160352041-1723https://doaj.org/article/e2d3db65188b4e788f0584c13918017c2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16035https://doaj.org/toc/2041-1723Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 polarization and associated type 2 immune responses.Zhipeng XuLei XuWei LiXin JinXian SongXiaojun ChenJifeng ZhuSha ZhouYong LiWeiwei ZhangXiaoxiao DongXiaowei YangFeng LiuHui BaiQi ChenChuan SuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhipeng Xu Lei Xu Wei Li Xin Jin Xian Song Xiaojun Chen Jifeng Zhu Sha Zhou Yong Li Weiwei Zhang Xiaoxiao Dong Xiaowei Yang Feng Liu Hui Bai Qi Chen Chuan Su Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
description	Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 polarization and associated type 2 immune responses.
format	article
author	Zhipeng Xu Lei Xu Wei Li Xin Jin Xian Song Xiaojun Chen Jifeng Zhu Sha Zhou Yong Li Weiwei Zhang Xiaoxiao Dong Xiaowei Yang Feng Liu Hui Bai Qi Chen Chuan Su
author_facet	Zhipeng Xu Lei Xu Wei Li Xin Jin Xian Song Xiaojun Chen Jifeng Zhu Sha Zhou Yong Li Weiwei Zhang Xiaoxiao Dong Xiaowei Yang Feng Liu Hui Bai Qi Chen Chuan Su
author_sort	Zhipeng Xu
title	Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_short	Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_full	Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_fullStr	Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_full_unstemmed	Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
title_sort	innate scavenger receptor-a regulates adaptive t helper cell responses to pathogen infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e2d3db65188b4e788f0584c13918017c
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Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

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