Advanced Glycation End-Products in Skeletal Muscle Aging

Advanced age causes skeletal muscle to undergo deleterious changes including muscle atrophy, fast-to-slow muscle fiber transition, and an increase in collagenous material that culminates in the age-dependent muscle wasting disease known as sarcopenia. Advanced glycation end-products (AGEs) non-enzym...

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Autores principales:	Lucas C. Olson, James T. Redden, Zvi Schwartz, David J. Cohen, Michael J. McClure
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	skeletal muscle aging sarcopenia advanced glycation end-products collagen collagen cross-linking motor nerve Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e2d4a466b8d940f4bebd22c16eed01a3
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spelling	oai:doaj.org-article:e2d4a466b8d940f4bebd22c16eed01a32021-11-25T16:46:30ZAdvanced Glycation End-Products in Skeletal Muscle Aging10.3390/bioengineering81101682306-5354https://doaj.org/article/e2d4a466b8d940f4bebd22c16eed01a32021-11-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/168https://doaj.org/toc/2306-5354Advanced age causes skeletal muscle to undergo deleterious changes including muscle atrophy, fast-to-slow muscle fiber transition, and an increase in collagenous material that culminates in the age-dependent muscle wasting disease known as sarcopenia. Advanced glycation end-products (AGEs) non-enzymatically accumulate on the muscular collagens in old age via the Maillard reaction, potentiating the accumulation of intramuscular collagen and stiffening the microenvironment through collagen cross-linking. This review contextualizes known aspects of skeletal muscle extracellular matrix (ECM) aging, especially the role of collagens and AGE cross-linking, and underpins the motor nerve’s role in this aging process. Specific directions for future research are also discussed, with the understudied role of AGEs in skeletal muscle aging highlighted. Despite more than a half century of research, the role that intramuscular collagen aggregation and cross-linking plays in sarcopenia is well accepted yet not well integrated with current knowledge of AGE’s effects on muscle physiology. Furthermore, the possible impact that motor nerve aging has on intramuscular cross-linking and muscular AGE levels is posited.Lucas C. OlsonJames T. ReddenZvi SchwartzDavid J. CohenMichael J. McClureMDPI AGarticleskeletal muscle agingsarcopeniaadvanced glycation end-productscollagencollagen cross-linkingmotor nerveTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 168, p 168 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skeletal muscle aging sarcopenia advanced glycation end-products collagen collagen cross-linking motor nerve Technology T Biology (General) QH301-705.5
spellingShingle	skeletal muscle aging sarcopenia advanced glycation end-products collagen collagen cross-linking motor nerve Technology T Biology (General) QH301-705.5 Lucas C. Olson James T. Redden Zvi Schwartz David J. Cohen Michael J. McClure Advanced Glycation End-Products in Skeletal Muscle Aging
description	Advanced age causes skeletal muscle to undergo deleterious changes including muscle atrophy, fast-to-slow muscle fiber transition, and an increase in collagenous material that culminates in the age-dependent muscle wasting disease known as sarcopenia. Advanced glycation end-products (AGEs) non-enzymatically accumulate on the muscular collagens in old age via the Maillard reaction, potentiating the accumulation of intramuscular collagen and stiffening the microenvironment through collagen cross-linking. This review contextualizes known aspects of skeletal muscle extracellular matrix (ECM) aging, especially the role of collagens and AGE cross-linking, and underpins the motor nerve’s role in this aging process. Specific directions for future research are also discussed, with the understudied role of AGEs in skeletal muscle aging highlighted. Despite more than a half century of research, the role that intramuscular collagen aggregation and cross-linking plays in sarcopenia is well accepted yet not well integrated with current knowledge of AGE’s effects on muscle physiology. Furthermore, the possible impact that motor nerve aging has on intramuscular cross-linking and muscular AGE levels is posited.
format	article
author	Lucas C. Olson James T. Redden Zvi Schwartz David J. Cohen Michael J. McClure
author_facet	Lucas C. Olson James T. Redden Zvi Schwartz David J. Cohen Michael J. McClure
author_sort	Lucas C. Olson
title	Advanced Glycation End-Products in Skeletal Muscle Aging
title_short	Advanced Glycation End-Products in Skeletal Muscle Aging
title_full	Advanced Glycation End-Products in Skeletal Muscle Aging
title_fullStr	Advanced Glycation End-Products in Skeletal Muscle Aging
title_full_unstemmed	Advanced Glycation End-Products in Skeletal Muscle Aging
title_sort	advanced glycation end-products in skeletal muscle aging
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e2d4a466b8d940f4bebd22c16eed01a3
work_keys_str_mv	AT lucascolson advancedglycationendproductsinskeletalmuscleaging AT jamestredden advancedglycationendproductsinskeletalmuscleaging AT zvischwartz advancedglycationendproductsinskeletalmuscleaging AT davidjcohen advancedglycationendproductsinskeletalmuscleaging AT michaeljmcclure advancedglycationendproductsinskeletalmuscleaging
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Advanced Glycation End-Products in Skeletal Muscle Aging

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