Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ sig...

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Autores principales:	Aleksandra Deczkowska, Orit Matcovitch-Natan, Afroditi Tsitsou-Kampeli, Sefi Ben-Hamo, Raz Dvir-Szternfeld, Amit Spinrad, Oded Singer, Eyal David, Deborah R. Winter, Lucas K. Smith, Alexander Kertser, Kuti Baruch, Neta Rosenzweig, Anna Terem, Marco Prinz, Saul Villeda, Ami Citri, Ido Amit, Michal Schwartz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2dc3b78b5264d47bfe7a706887e8f6c
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spelling	oai:doaj.org-article:e2dc3b78b5264d47bfe7a706887e8f6c2021-12-02T14:40:46ZMef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner10.1038/s41467-017-00769-02041-1723https://doaj.org/article/e2dc3b78b5264d47bfe7a706887e8f6c2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00769-0https://doaj.org/toc/2041-1723Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ signal.Aleksandra DeczkowskaOrit Matcovitch-NatanAfroditi Tsitsou-KampeliSefi Ben-HamoRaz Dvir-SzternfeldAmit SpinradOded SingerEyal DavidDeborah R. WinterLucas K. SmithAlexander KertserKuti BaruchNeta RosenzweigAnna TeremMarco PrinzSaul VilledaAmi CitriIdo AmitMichal SchwartzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aleksandra Deczkowska Orit Matcovitch-Natan Afroditi Tsitsou-Kampeli Sefi Ben-Hamo Raz Dvir-Szternfeld Amit Spinrad Oded Singer Eyal David Deborah R. Winter Lucas K. Smith Alexander Kertser Kuti Baruch Neta Rosenzweig Anna Terem Marco Prinz Saul Villeda Ami Citri Ido Amit Michal Schwartz Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
description	Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ signal.
format	article
author	Aleksandra Deczkowska Orit Matcovitch-Natan Afroditi Tsitsou-Kampeli Sefi Ben-Hamo Raz Dvir-Szternfeld Amit Spinrad Oded Singer Eyal David Deborah R. Winter Lucas K. Smith Alexander Kertser Kuti Baruch Neta Rosenzweig Anna Terem Marco Prinz Saul Villeda Ami Citri Ido Amit Michal Schwartz
author_facet	Aleksandra Deczkowska Orit Matcovitch-Natan Afroditi Tsitsou-Kampeli Sefi Ben-Hamo Raz Dvir-Szternfeld Amit Spinrad Oded Singer Eyal David Deborah R. Winter Lucas K. Smith Alexander Kertser Kuti Baruch Neta Rosenzweig Anna Terem Marco Prinz Saul Villeda Ami Citri Ido Amit Michal Schwartz
author_sort	Aleksandra Deczkowska
title	Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
title_short	Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
title_full	Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
title_fullStr	Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
title_full_unstemmed	Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
title_sort	mef2c restrains microglial inflammatory response and is lost in brain ageing in an ifn-i-dependent manner
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e2dc3b78b5264d47bfe7a706887e8f6c
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Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

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