Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
Microglia cells in the brain regulate immune responses, but in ageing can negatively affect brain function. Here the authors show that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglia ‘off’ sig...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/e2dc3b78b5264d47bfe7a706887e8f6c |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|