Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid

Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic hea...

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Autores principales:	Habala L., Pašková L., Bilková A., Bilka F., Oboňová B., Valentová J.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	bioinorganic chemistry metallodrugs agaric acid anticancer antimicrobial amphiphilic compounds Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e2dc6ca710fc421db7d5fb2705199dc8
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spelling	oai:doaj.org-article:e2dc6ca710fc421db7d5fb2705199dc82021-12-05T14:11:05ZAntimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid2453-672510.2478/afpuc-2020-0018https://doaj.org/article/e2dc6ca710fc421db7d5fb2705199dc82021-07-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2020-0018https://doaj.org/toc/2453-6725Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic head (citric acid moiety) and a hydrophobic tail (non-polar alkyl chain). The putative composition of the carboxylates was assigned on grounds of elemental analysis, infrared (IR) and high-resolution mass spectra (HR-MS), as well as in analogy with known complexes containing the citrate moiety. The metal carboxylates showed interesting activity in several microbial strains, especially against S. aureus (vanadium complex; MIC = 0.05 mg/ml). They were also tested for their cytotoxic activity in hepatocytes, the highest activity having been found in the copper(II) and manganese(II) complexes. Further research based on these preliminary results is needed in order to evaluate the influence of parameters like stability of the metal complexes in solution on the bioactivity of the complexes.Habala L.Pašková L.Bilková A.Bilka F.Oboňová B.Valentová J.Sciendoarticlebioinorganic chemistrymetallodrugsagaric acidanticancerantimicrobialamphiphilic compoundsTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 46-53 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioinorganic chemistry metallodrugs agaric acid anticancer antimicrobial amphiphilic compounds Therapeutics. Pharmacology RM1-950
spellingShingle	bioinorganic chemistry metallodrugs agaric acid anticancer antimicrobial amphiphilic compounds Therapeutics. Pharmacology RM1-950 Habala L. Pašková L. Bilková A. Bilka F. Oboňová B. Valentová J. Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
description	Carboxylato-type transition metal complexes with agaric acid, a bioactive natural compound derived from citric acid, were prepared, and tested in vitro for their antimicrobial activity and cytotoxicity. The products as well as agaric acid itself are amphiphilic compounds containing a hydrophilic head (citric acid moiety) and a hydrophobic tail (non-polar alkyl chain). The putative composition of the carboxylates was assigned on grounds of elemental analysis, infrared (IR) and high-resolution mass spectra (HR-MS), as well as in analogy with known complexes containing the citrate moiety. The metal carboxylates showed interesting activity in several microbial strains, especially against S. aureus (vanadium complex; MIC = 0.05 mg/ml). They were also tested for their cytotoxic activity in hepatocytes, the highest activity having been found in the copper(II) and manganese(II) complexes. Further research based on these preliminary results is needed in order to evaluate the influence of parameters like stability of the metal complexes in solution on the bioactivity of the complexes.
format	article
author	Habala L. Pašková L. Bilková A. Bilka F. Oboňová B. Valentová J.
author_facet	Habala L. Pašková L. Bilková A. Bilka F. Oboňová B. Valentová J.
author_sort	Habala L.
title	Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
title_short	Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
title_full	Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
title_fullStr	Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
title_full_unstemmed	Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
title_sort	antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/e2dc6ca710fc421db7d5fb2705199dc8
work_keys_str_mv	AT habalal antimicrobialactivityandcytotoxicityoftransitionmetalcarboxylatesderivedfromagaricacid AT paskoval antimicrobialactivityandcytotoxicityoftransitionmetalcarboxylatesderivedfromagaricacid AT bilkovaa antimicrobialactivityandcytotoxicityoftransitionmetalcarboxylatesderivedfromagaricacid AT bilkaf antimicrobialactivityandcytotoxicityoftransitionmetalcarboxylatesderivedfromagaricacid AT obonovab antimicrobialactivityandcytotoxicityoftransitionmetalcarboxylatesderivedfromagaricacid AT valentovaj antimicrobialactivityandcytotoxicityoftransitionmetalcarboxylatesderivedfromagaricacid
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Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid

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