Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study

Kerebih Bantigen,1 Leul Kitaw,1 Haweni Negeri,1 Mekonen Kebede,1 Addisu Wassie,2 Keralem Bishaw,3 Getaye Tesema4 1Nursing and Midwifery, Addis Ababa University, Addis Ababa, Ethiopia; 2Midwifery, Welayita Sodo University, Welayita Sodo, Ethiopia; 3Midwifery, Debre Markos University, Debre Markos, Et...

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Autores principales:	Bantigen K, Kitaw L, Negeri H, Kebede M, Wassie A, Bishaw K, Tesema G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hiv discordant couple sero-conversion rate ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e2dd452521c64685ab26221965397f01
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spelling	oai:doaj.org-article:e2dd452521c64685ab26221965397f012021-12-02T12:14:54ZRate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study1179-1373https://doaj.org/article/e2dd452521c64685ab26221965397f012021-02-01T00:00:00Zhttps://www.dovepress.com/rate-of-hiv-seroconversion-among-seronegative-male-partners-living-wit-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Kerebih Bantigen,1 Leul Kitaw,1 Haweni Negeri,1 Mekonen Kebede,1 Addisu Wassie,2 Keralem Bishaw,3 Getaye Tesema4 1Nursing and Midwifery, Addis Ababa University, Addis Ababa, Ethiopia; 2Midwifery, Welayita Sodo University, Welayita Sodo, Ethiopia; 3Midwifery, Debre Markos University, Debre Markos, Ethiopia; 4Midwifery, Debreberhan University, Debreberhan, EthiopiaCorrespondence: Kerebih BantigenNursing and Midwifery, Addis Ababa University, Addis Ababa, EthiopiaTel +251 991134859Email kerebihab2015@gmial.comObjective: This study aimed to assess rate of HIV seroconversion and predictors among seronegative male partners living with HIV-positive women in Addis Ababa, Ethiopia, 2019.Methods: Institutional-based retrospective cohort was used to conduct the study. All eligible 227 sample medical records were used for the study. Kaplan–Meier analysis was used to estimate seroconversion time. Cox proportional-hazard regression was used to identify predictor variables.Results: In this study, 227 seronegative male partners living with HIV-positive women were followed for 60 months retrospectively and 38 (16.7%) seroconversion was observed. The overall seroconversion rate was 6.4 (95%CI: 4.64– 8.76) per 100 person-year observation. Time of antiretroviral therapy (ART) initiation, CD4 level, condom use, and having history of pregnancy after being diagnosed as discordant were identified significant predictors of seroconversion.Conclusion: The risk of HIV transmission from seropositive partner to seronegative partner in a discordant couple is poorly controlled. Seronegative partners in discordant a couple can be seropositive at any time with influence of predictors unless proper protective measures, counseling, and follow-up are given emphasis.Keywords: HIV, discordant couple, seroconversion rate, EthiopiaBantigen KKitaw LNegeri HKebede MWassie ABishaw KTesema GDove Medical Pressarticlehivdiscordant couplesero-conversion rateethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 125-134 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv discordant couple sero-conversion rate ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	hiv discordant couple sero-conversion rate ethiopia Immunologic diseases. Allergy RC581-607 Bantigen K Kitaw L Negeri H Kebede M Wassie A Bishaw K Tesema G Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study
description	Kerebih Bantigen,1 Leul Kitaw,1 Haweni Negeri,1 Mekonen Kebede,1 Addisu Wassie,2 Keralem Bishaw,3 Getaye Tesema4 1Nursing and Midwifery, Addis Ababa University, Addis Ababa, Ethiopia; 2Midwifery, Welayita Sodo University, Welayita Sodo, Ethiopia; 3Midwifery, Debre Markos University, Debre Markos, Ethiopia; 4Midwifery, Debreberhan University, Debreberhan, EthiopiaCorrespondence: Kerebih BantigenNursing and Midwifery, Addis Ababa University, Addis Ababa, EthiopiaTel +251 991134859Email kerebihab2015@gmial.comObjective: This study aimed to assess rate of HIV seroconversion and predictors among seronegative male partners living with HIV-positive women in Addis Ababa, Ethiopia, 2019.Methods: Institutional-based retrospective cohort was used to conduct the study. All eligible 227 sample medical records were used for the study. Kaplan–Meier analysis was used to estimate seroconversion time. Cox proportional-hazard regression was used to identify predictor variables.Results: In this study, 227 seronegative male partners living with HIV-positive women were followed for 60 months retrospectively and 38 (16.7%) seroconversion was observed. The overall seroconversion rate was 6.4 (95%CI: 4.64– 8.76) per 100 person-year observation. Time of antiretroviral therapy (ART) initiation, CD4 level, condom use, and having history of pregnancy after being diagnosed as discordant were identified significant predictors of seroconversion.Conclusion: The risk of HIV transmission from seropositive partner to seronegative partner in a discordant couple is poorly controlled. Seronegative partners in discordant a couple can be seropositive at any time with influence of predictors unless proper protective measures, counseling, and follow-up are given emphasis.Keywords: HIV, discordant couple, seroconversion rate, Ethiopia
format	article
author	Bantigen K Kitaw L Negeri H Kebede M Wassie A Bishaw K Tesema G
author_facet	Bantigen K Kitaw L Negeri H Kebede M Wassie A Bishaw K Tesema G
author_sort	Bantigen K
title	Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study
title_short	Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study
title_full	Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study
title_fullStr	Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study
title_full_unstemmed	Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study
title_sort	rate of hiv seroconversion among seronegative male partners living with hiv positive women in addis ababa, ethiopia, 2019: a retrospective cohort study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e2dd452521c64685ab26221965397f01
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Rate of HIV Seroconversion Among Seronegative Male Partners Living with HIV Positive Women in Addis Ababa, Ethiopia, 2019: A Retrospective Cohort Study

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