The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats

Brain hemorrhage: Reducing inflammation and brain damage Treatments that target the proteins responsible for inflammation might reduce brain damage after a hemorrhage. Sudden bleeding into the brain, known as intracerebral hemorrhage (ICH), is associated with strokes and head injuries. Inflammation...

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Autores principales:	Hui Gan, Li Zhang, Hui Chen, Han Xiao, Lu Wang, Xuan Zhai, Ning Jiang, Ping Liang, Shuyue Zheng, Jing Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/e2e9421fccc442c29e2cb7bd3e6d00d9
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spelling	oai:doaj.org-article:e2e9421fccc442c29e2cb7bd3e6d00d92021-12-05T12:24:24ZThe pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats10.1038/s12276-021-00702-y1226-36132092-6413https://doaj.org/article/e2e9421fccc442c29e2cb7bd3e6d00d92021-11-01T00:00:00Zhttps://doi.org/10.1038/s12276-021-00702-yhttps://doaj.org/toc/1226-3613https://doaj.org/toc/2092-6413Brain hemorrhage: Reducing inflammation and brain damage Treatments that target the proteins responsible for inflammation might reduce brain damage after a hemorrhage. Sudden bleeding into the brain, known as intracerebral hemorrhage (ICH), is associated with strokes and head injuries. Inflammation exacerbates ICH-induced injury after an incident, and is activated by protein complexes called inflammasomes. Jing Zhao and co-workers at Chongqing Medical University in China induced ICH symptoms in rats by extracting arterial blood and injecting it into the basal ganglia of the brain. When they artificially blocked expression of the inflammasome NLRC4, they saw reductions in neuron death, brain edema and damage to the blood-brain barrier. The team also identified a protein critical for activating NLRC4 and another protein that suppresses NLRC4. These findings could aid the development of treatments to block NLRC4 in the days after an ICH.Hui GanLi ZhangHui ChenHan XiaoLu WangXuan ZhaiNing JiangPing LiangShuyue ZhengJing ZhaoNature Publishing GrouparticleMedicineRBiochemistryQD415-436ENExperimental and Molecular Medicine, Vol 53, Iss 11, Pp 1807-1818 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biochemistry QD415-436
spellingShingle	Medicine R Biochemistry QD415-436 Hui Gan Li Zhang Hui Chen Han Xiao Lu Wang Xuan Zhai Ning Jiang Ping Liang Shuyue Zheng Jing Zhao The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
description	Brain hemorrhage: Reducing inflammation and brain damage Treatments that target the proteins responsible for inflammation might reduce brain damage after a hemorrhage. Sudden bleeding into the brain, known as intracerebral hemorrhage (ICH), is associated with strokes and head injuries. Inflammation exacerbates ICH-induced injury after an incident, and is activated by protein complexes called inflammasomes. Jing Zhao and co-workers at Chongqing Medical University in China induced ICH symptoms in rats by extracting arterial blood and injecting it into the basal ganglia of the brain. When they artificially blocked expression of the inflammasome NLRC4, they saw reductions in neuron death, brain edema and damage to the blood-brain barrier. The team also identified a protein critical for activating NLRC4 and another protein that suppresses NLRC4. These findings could aid the development of treatments to block NLRC4 in the days after an ICH.
format	article
author	Hui Gan Li Zhang Hui Chen Han Xiao Lu Wang Xuan Zhai Ning Jiang Ping Liang Shuyue Zheng Jing Zhao
author_facet	Hui Gan Li Zhang Hui Chen Han Xiao Lu Wang Xuan Zhai Ning Jiang Ping Liang Shuyue Zheng Jing Zhao
author_sort	Hui Gan
title	The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
title_short	The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
title_full	The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
title_fullStr	The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
title_full_unstemmed	The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
title_sort	pivotal role of the nlrc4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/e2e9421fccc442c29e2cb7bd3e6d00d9
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The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats

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