Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy

Abstract Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sejy Lee, Reju George Thomas, Myeong Ju Moon, Hyeong Ju Park, In-Kyu Park, Byeong-Il Lee, Yong Yeon Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e2edd4337e674b469fec473e84d14507
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e2edd4337e674b469fec473e84d14507
record_format	dspace
spelling	oai:doaj.org-article:e2edd4337e674b469fec473e84d145072021-12-02T12:32:57ZNear-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy10.1038/s41598-017-01108-52045-2322https://doaj.org/article/e2edd4337e674b469fec473e84d145072017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01108-5https://doaj.org/toc/2045-2322Abstract Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good option because MRI can provide anatomical information with a higher resolution. Heptamethine cyanine dye (MHI-148) has been reported to have tumor-targeting capability which was used here as the NIRF agent. DSPE-SPION nanoparticles were synthesized by the solvent hydration method and conjugated with MHI-148 dye to form a MRI/NIRF dual imaging probe. The size and charge of the MHI-DSPE-SPION were found to be about 84 ± 6 nm and 3.7 mV by DLS & Zeta Potential analysis. In vivo MRI of the SCC7 tumor showed an enhanced accumulation of MHI-DSPE-SPION, peaking at day 1, compared to 4 hrs with the control DSPE-SPION. An in vivo photothermal tumor reduction study was done on the SCC7 tumor of BALB/c nude mice. Tumor reduction study showed complete tumor removal after 8 days. In conclusion, MHI-DSPE-SPION can be used as a cancer theranostics material because it provides MRI-optical imaging capabilities and the photothermal therapy (PTT) effect.Sejy LeeReju George ThomasMyeong Ju MoonHyeong Ju ParkIn-Kyu ParkByeong-Il LeeYong Yeon JeongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sejy Lee Reju George Thomas Myeong Ju Moon Hyeong Ju Park In-Kyu Park Byeong-Il Lee Yong Yeon Jeong Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy
description	Abstract Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good option because MRI can provide anatomical information with a higher resolution. Heptamethine cyanine dye (MHI-148) has been reported to have tumor-targeting capability which was used here as the NIRF agent. DSPE-SPION nanoparticles were synthesized by the solvent hydration method and conjugated with MHI-148 dye to form a MRI/NIRF dual imaging probe. The size and charge of the MHI-DSPE-SPION were found to be about 84 ± 6 nm and 3.7 mV by DLS & Zeta Potential analysis. In vivo MRI of the SCC7 tumor showed an enhanced accumulation of MHI-DSPE-SPION, peaking at day 1, compared to 4 hrs with the control DSPE-SPION. An in vivo photothermal tumor reduction study was done on the SCC7 tumor of BALB/c nude mice. Tumor reduction study showed complete tumor removal after 8 days. In conclusion, MHI-DSPE-SPION can be used as a cancer theranostics material because it provides MRI-optical imaging capabilities and the photothermal therapy (PTT) effect.
format	article
author	Sejy Lee Reju George Thomas Myeong Ju Moon Hyeong Ju Park In-Kyu Park Byeong-Il Lee Yong Yeon Jeong
author_facet	Sejy Lee Reju George Thomas Myeong Ju Moon Hyeong Ju Park In-Kyu Park Byeong-Il Lee Yong Yeon Jeong
author_sort	Sejy Lee
title	Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy
title_short	Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy
title_full	Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy
title_fullStr	Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy
title_full_unstemmed	Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy
title_sort	near-infrared heptamethine cyanine based iron oxide nanoparticles for tumor targeted multimodal imaging and photothermal therapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e2edd4337e674b469fec473e84d14507
work_keys_str_mv	AT sejylee nearinfraredheptamethinecyaninebasedironoxidenanoparticlesfortumortargetedmultimodalimagingandphotothermaltherapy AT rejugeorgethomas nearinfraredheptamethinecyaninebasedironoxidenanoparticlesfortumortargetedmultimodalimagingandphotothermaltherapy AT myeongjumoon nearinfraredheptamethinecyaninebasedironoxidenanoparticlesfortumortargetedmultimodalimagingandphotothermaltherapy AT hyeongjupark nearinfraredheptamethinecyaninebasedironoxidenanoparticlesfortumortargetedmultimodalimagingandphotothermaltherapy AT inkyupark nearinfraredheptamethinecyaninebasedironoxidenanoparticlesfortumortargetedmultimodalimagingandphotothermaltherapy AT byeongillee nearinfraredheptamethinecyaninebasedironoxidenanoparticlesfortumortargetedmultimodalimagingandphotothermaltherapy AT yongyeonjeong nearinfraredheptamethinecyaninebasedironoxidenanoparticlesfortumortargetedmultimodalimagingandphotothermaltherapy
_version_	1718393951569838080

Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy

Ejemplares similares