Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression

Multiple myeloma (MM) progression closely depends on the bidirectional crosstalk between tumor cells and the surrounding microenvironment, which leads to the creation of a tumor supportive niche. Extracellular vesicles (EVs) have emerged as key players in the pathological interplay between the malig...

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Autores principales:	Ilaria Saltarella, Aurelia Lamanuzzi, Benedetta Apollonio, Vanessa Desantis, Giulia Bartoli, Angelo Vacca, Maria Antonia Frassanito
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple myeloma extracellular vesicles bone marrow microenvironment miRNAs Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e2f631e438b74a0b991f3529a1f4e3d8
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id	oai:doaj.org-article:e2f631e438b74a0b991f3529a1f4e3d8
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spelling	oai:doaj.org-article:e2f631e438b74a0b991f3529a1f4e3d82021-11-25T17:12:33ZRole of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression10.3390/cells101131852073-4409https://doaj.org/article/e2f631e438b74a0b991f3529a1f4e3d82021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3185https://doaj.org/toc/2073-4409Multiple myeloma (MM) progression closely depends on the bidirectional crosstalk between tumor cells and the surrounding microenvironment, which leads to the creation of a tumor supportive niche. Extracellular vesicles (EVs) have emerged as key players in the pathological interplay between the malignant clone and near/distal bone marrow (BM) cells through their biologically active cargo. Here, we describe the role of EVs derived from MM and BM cells in reprogramming the tumor microenvironment and in fostering bone disease, angiogenesis, immunosuppression, drug resistance, and, ultimately, tumor progression. We also examine the emerging role of EVs as new therapeutic agents for the treatment of MM, and their potential use as clinical biomarkers for early diagnosis, disease classification, and therapy monitoring.Ilaria SaltarellaAurelia LamanuzziBenedetta ApollonioVanessa DesantisGiulia BartoliAngelo VaccaMaria Antonia FrassanitoMDPI AGarticlemultiple myelomaextracellular vesiclesbone marrow microenvironmentmiRNAsBiology (General)QH301-705.5ENCells, Vol 10, Iss 3185, p 3185 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple myeloma extracellular vesicles bone marrow microenvironment miRNAs Biology (General) QH301-705.5
spellingShingle	multiple myeloma extracellular vesicles bone marrow microenvironment miRNAs Biology (General) QH301-705.5 Ilaria Saltarella Aurelia Lamanuzzi Benedetta Apollonio Vanessa Desantis Giulia Bartoli Angelo Vacca Maria Antonia Frassanito Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression
description	Multiple myeloma (MM) progression closely depends on the bidirectional crosstalk between tumor cells and the surrounding microenvironment, which leads to the creation of a tumor supportive niche. Extracellular vesicles (EVs) have emerged as key players in the pathological interplay between the malignant clone and near/distal bone marrow (BM) cells through their biologically active cargo. Here, we describe the role of EVs derived from MM and BM cells in reprogramming the tumor microenvironment and in fostering bone disease, angiogenesis, immunosuppression, drug resistance, and, ultimately, tumor progression. We also examine the emerging role of EVs as new therapeutic agents for the treatment of MM, and their potential use as clinical biomarkers for early diagnosis, disease classification, and therapy monitoring.
format	article
author	Ilaria Saltarella Aurelia Lamanuzzi Benedetta Apollonio Vanessa Desantis Giulia Bartoli Angelo Vacca Maria Antonia Frassanito
author_facet	Ilaria Saltarella Aurelia Lamanuzzi Benedetta Apollonio Vanessa Desantis Giulia Bartoli Angelo Vacca Maria Antonia Frassanito
author_sort	Ilaria Saltarella
title	Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression
title_short	Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression
title_full	Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression
title_fullStr	Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression
title_full_unstemmed	Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression
title_sort	role of extracellular vesicle-based cell-to-cell communication in multiple myeloma progression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e2f631e438b74a0b991f3529a1f4e3d8
work_keys_str_mv	AT ilariasaltarella roleofextracellularvesiclebasedcelltocellcommunicationinmultiplemyelomaprogression AT aurelialamanuzzi roleofextracellularvesiclebasedcelltocellcommunicationinmultiplemyelomaprogression AT benedettaapollonio roleofextracellularvesiclebasedcelltocellcommunicationinmultiplemyelomaprogression AT vanessadesantis roleofextracellularvesiclebasedcelltocellcommunicationinmultiplemyelomaprogression AT giuliabartoli roleofextracellularvesiclebasedcelltocellcommunicationinmultiplemyelomaprogression AT angelovacca roleofextracellularvesiclebasedcelltocellcommunicationinmultiplemyelomaprogression AT mariaantoniafrassanito roleofextracellularvesiclebasedcelltocellcommunicationinmultiplemyelomaprogression
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Role of Extracellular Vesicle-Based Cell-to-Cell Communication in Multiple Myeloma Progression

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