Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

Aberrant activation of NRF2 in cancer cells contributes to tumorigenicity and therapeutic resistance. Here, the authors show that NRF2 cooperates with CEBPB and remodels enhancers to confer tumor-initiating activity on NRF2- activated non-small cell lung cancers.

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Autores principales:	Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md. Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2fd0ce97bcb4b3aabb6a909e9e673dd
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spelling	oai:doaj.org-article:e2fd0ce97bcb4b3aabb6a909e9e673dd2021-12-02T14:43:01ZEnhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers10.1038/s41467-020-19593-02041-1723https://doaj.org/article/e2fd0ce97bcb4b3aabb6a909e9e673dd2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19593-0https://doaj.org/toc/2041-1723Aberrant activation of NRF2 in cancer cells contributes to tumorigenicity and therapeutic resistance. Here, the authors show that NRF2 cooperates with CEBPB and remodels enhancers to confer tumor-initiating activity on NRF2- activated non-small cell lung cancers.Keito OkazakiHayato AnzawaZun LiuNao OtaHiroshi KitamuraYoshiaki OnoderaMd. Morshedul AlamDaisuke MatsumaruTakuma SuzukiFumiki KatsuokaShu TadakaIkuko MotoikeMika WatanabeKazuki HayasakaAkira SakuradaYoshinori OkadaMasayuki YamamotoTakashi SuzukiKengo KinoshitaHiroki SekineHozumi MotohashiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keito Okazaki Hayato Anzawa Zun Liu Nao Ota Hiroshi Kitamura Yoshiaki Onodera Md. Morshedul Alam Daisuke Matsumaru Takuma Suzuki Fumiki Katsuoka Shu Tadaka Ikuko Motoike Mika Watanabe Kazuki Hayasaka Akira Sakurada Yoshinori Okada Masayuki Yamamoto Takashi Suzuki Kengo Kinoshita Hiroki Sekine Hozumi Motohashi Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
description	Aberrant activation of NRF2 in cancer cells contributes to tumorigenicity and therapeutic resistance. Here, the authors show that NRF2 cooperates with CEBPB and remodels enhancers to confer tumor-initiating activity on NRF2- activated non-small cell lung cancers.
format	article
author	Keito Okazaki Hayato Anzawa Zun Liu Nao Ota Hiroshi Kitamura Yoshiaki Onodera Md. Morshedul Alam Daisuke Matsumaru Takuma Suzuki Fumiki Katsuoka Shu Tadaka Ikuko Motoike Mika Watanabe Kazuki Hayasaka Akira Sakurada Yoshinori Okada Masayuki Yamamoto Takashi Suzuki Kengo Kinoshita Hiroki Sekine Hozumi Motohashi
author_facet	Keito Okazaki Hayato Anzawa Zun Liu Nao Ota Hiroshi Kitamura Yoshiaki Onodera Md. Morshedul Alam Daisuke Matsumaru Takuma Suzuki Fumiki Katsuoka Shu Tadaka Ikuko Motoike Mika Watanabe Kazuki Hayasaka Akira Sakurada Yoshinori Okada Masayuki Yamamoto Takashi Suzuki Kengo Kinoshita Hiroki Sekine Hozumi Motohashi
author_sort	Keito Okazaki
title	Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
title_short	Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
title_full	Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
title_fullStr	Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
title_full_unstemmed	Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
title_sort	enhancer remodeling promotes tumor-initiating activity in nrf2-activated non-small cell lung cancers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e2fd0ce97bcb4b3aabb6a909e9e673dd
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Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers

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