Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes

The correlation between residual mitral regurgitation (rMR) grade or mitral valve pressure gradient (MVPG), at transcatheter edge-to-edge mitral valve repair (TEEMr) completion and at discharge, is unknown. Furthermore, there is disagreement regarding rMR grade or MVPG from which prognosis diverts....

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Autores principales:	Doron Sudarsky, Fabio Kusniec, Liza Grosman-Rimon, Ala Lubovich, Wadia Kinany, Evgeni Hazanov, Michael Gelbstein, Edo Y. Birati, Shemy Carasso
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	transcatheter edge-to-edge mitral valve repair residual mitral regurgitation mitral valve pressure gradient Medicine R
Acceso en línea:	https://doaj.org/article/e2ffd8ce221f48ae844ce3c535a9e313
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spelling	oai:doaj.org-article:e2ffd8ce221f48ae844ce3c535a9e3132021-11-25T18:02:56ZImmediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes10.3390/jcm102254482077-0383https://doaj.org/article/e2ffd8ce221f48ae844ce3c535a9e3132021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5448https://doaj.org/toc/2077-0383The correlation between residual mitral regurgitation (rMR) grade or mitral valve pressure gradient (MVPG), at transcatheter edge-to-edge mitral valve repair (TEEMr) completion and at discharge, is unknown. Furthermore, there is disagreement regarding rMR grade or MVPG from which prognosis diverts. We retrospectively studied 82 patients that underwent TEEMr. We tested the correlation between rMR or MVPG and evaluated their association, with outcomes. Moderate or less rMR (rMR ≤ 2) at TEEMr completion was associated with improved survival, whereas mild or less rMR (rMR ≤ 1) was not. Patients with rMR ≤ 1 at discharge demonstrated a longer time of survival, of first heart failure hospitalization and of both. The correlation for both rMR grade (<i>r</i> = 0.5, <i>p</i> < 0.001) and MVPG (<i>r</i> = 0.51, <i>p</i> < 0.001), between TEEMr completion and discharge, was moderate. MR ≤ 2 at TMEER completion was the strongest predictor for survival (HR 0.08, <i>p</i> < 0.001) whereas rMR ≤ 1 at discharge was independently associated with a lower risk of the combined endpoint (HR 4.17, <i>p</i> = 0.012). MVPG was not associated with adverse events. We conclude that the assessments for rMR grade and MVPG, at the completion of TEEMr and at discharge, should be distinctly reported. Improved outcome is expected with rMR ≤ 2 at TEEMr completion and rMR ≤ 1 at discharge. Higher MVPG is not associated with unfavorable outcomes.Doron SudarskyFabio KusniecLiza Grosman-RimonAla LubovichWadia KinanyEvgeni HazanovMichael GelbsteinEdo Y. BiratiShemy CarassoMDPI AGarticletranscatheter edge-to-edge mitral valve repairresidual mitral regurgitationmitral valve pressure gradientMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5448, p 5448 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transcatheter edge-to-edge mitral valve repair residual mitral regurgitation mitral valve pressure gradient Medicine R
spellingShingle	transcatheter edge-to-edge mitral valve repair residual mitral regurgitation mitral valve pressure gradient Medicine R Doron Sudarsky Fabio Kusniec Liza Grosman-Rimon Ala Lubovich Wadia Kinany Evgeni Hazanov Michael Gelbstein Edo Y. Birati Shemy Carasso Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes
description	The correlation between residual mitral regurgitation (rMR) grade or mitral valve pressure gradient (MVPG), at transcatheter edge-to-edge mitral valve repair (TEEMr) completion and at discharge, is unknown. Furthermore, there is disagreement regarding rMR grade or MVPG from which prognosis diverts. We retrospectively studied 82 patients that underwent TEEMr. We tested the correlation between rMR or MVPG and evaluated their association, with outcomes. Moderate or less rMR (rMR ≤ 2) at TEEMr completion was associated with improved survival, whereas mild or less rMR (rMR ≤ 1) was not. Patients with rMR ≤ 1 at discharge demonstrated a longer time of survival, of first heart failure hospitalization and of both. The correlation for both rMR grade (<i>r</i> = 0.5, <i>p</i> < 0.001) and MVPG (<i>r</i> = 0.51, <i>p</i> < 0.001), between TEEMr completion and discharge, was moderate. MR ≤ 2 at TMEER completion was the strongest predictor for survival (HR 0.08, <i>p</i> < 0.001) whereas rMR ≤ 1 at discharge was independently associated with a lower risk of the combined endpoint (HR 4.17, <i>p</i> = 0.012). MVPG was not associated with adverse events. We conclude that the assessments for rMR grade and MVPG, at the completion of TEEMr and at discharge, should be distinctly reported. Improved outcome is expected with rMR ≤ 2 at TEEMr completion and rMR ≤ 1 at discharge. Higher MVPG is not associated with unfavorable outcomes.
format	article
author	Doron Sudarsky Fabio Kusniec Liza Grosman-Rimon Ala Lubovich Wadia Kinany Evgeni Hazanov Michael Gelbstein Edo Y. Birati Shemy Carasso
author_facet	Doron Sudarsky Fabio Kusniec Liza Grosman-Rimon Ala Lubovich Wadia Kinany Evgeni Hazanov Michael Gelbstein Edo Y. Birati Shemy Carasso
author_sort	Doron Sudarsky
title	Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes
title_short	Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes
title_full	Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes
title_fullStr	Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes
title_full_unstemmed	Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes
title_sort	immediate post-procedural and discharge assessment of mitral valve function following transcatheter edge-to-edge mitral valve repair: correlation and association with outcomes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e2ffd8ce221f48ae844ce3c535a9e313
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Immediate Post-Procedural and Discharge Assessment of Mitral Valve Function Following Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation and Association with Outcomes

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