Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells

Stem cells aging: balancing self-renewal halt with complexity Mounting evidence suggests a link between cellular senescence and human adult stem cell function upon aging. Senescence is often viewed as an intrinsic program to prevent oncogenic transformation. However, the collaborative research lead...

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Autores principales:	Mary F. Lopez, Ping Niu, Lu Wang, Maryann Vogelsang, Meenakshi Gaur, Bryan Krastins, Yueqiang Zhao, Aibek Smagul, Aliya Nussupbekova, Aikan A. Akanov, I. King Jordan, Victoria V. Lunyak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e3010ed26bd14b8ca45b854bb7cfd1b4
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spelling	oai:doaj.org-article:e3010ed26bd14b8ca45b854bb7cfd1b42021-12-02T14:22:33ZOpposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells10.1038/s41514-017-0006-y2056-3973https://doaj.org/article/e3010ed26bd14b8ca45b854bb7cfd1b42017-04-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0006-yhttps://doaj.org/toc/2056-3973Stem cells aging: balancing self-renewal halt with complexity Mounting evidence suggests a link between cellular senescence and human adult stem cell function upon aging. Senescence is often viewed as an intrinsic program to prevent oncogenic transformation. However, the collaborative research lead by Aelan Cell Technologies suggests that replicative senescence might be more dynamic than previously anticipated. Integrated genomic and proteomic analyses of human adult stem cells revealed that subset of senescence-associated miRNAs (SA-miRNA) functionally required for establishing senescence, act to provide an intricate balance between driving and restraining cancerous events upon senescence. It is commonly believed that cancer arises as a consequence of an imbalance in cellular homeostasis. These new results shed light on the fundamental role of these SA-miRNA as functionally antagonistic regulators of gene networks, future exploration of which can help us understand the etiology underlying age-related disease and cancer.Mary F. LopezPing NiuLu WangMaryann VogelsangMeenakshi GaurBryan KrastinsYueqiang ZhaoAibek SmagulAliya NussupbekovaAikan A. AkanovI. King JordanVictoria V. LunyakNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Mary F. Lopez Ping Niu Lu Wang Maryann Vogelsang Meenakshi Gaur Bryan Krastins Yueqiang Zhao Aibek Smagul Aliya Nussupbekova Aikan A. Akanov I. King Jordan Victoria V. Lunyak Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells
description	Stem cells aging: balancing self-renewal halt with complexity Mounting evidence suggests a link between cellular senescence and human adult stem cell function upon aging. Senescence is often viewed as an intrinsic program to prevent oncogenic transformation. However, the collaborative research lead by Aelan Cell Technologies suggests that replicative senescence might be more dynamic than previously anticipated. Integrated genomic and proteomic analyses of human adult stem cells revealed that subset of senescence-associated miRNAs (SA-miRNA) functionally required for establishing senescence, act to provide an intricate balance between driving and restraining cancerous events upon senescence. It is commonly believed that cancer arises as a consequence of an imbalance in cellular homeostasis. These new results shed light on the fundamental role of these SA-miRNA as functionally antagonistic regulators of gene networks, future exploration of which can help us understand the etiology underlying age-related disease and cancer.
format	article
author	Mary F. Lopez Ping Niu Lu Wang Maryann Vogelsang Meenakshi Gaur Bryan Krastins Yueqiang Zhao Aibek Smagul Aliya Nussupbekova Aikan A. Akanov I. King Jordan Victoria V. Lunyak
author_facet	Mary F. Lopez Ping Niu Lu Wang Maryann Vogelsang Meenakshi Gaur Bryan Krastins Yueqiang Zhao Aibek Smagul Aliya Nussupbekova Aikan A. Akanov I. King Jordan Victoria V. Lunyak
author_sort	Mary F. Lopez
title	Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells
title_short	Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells
title_full	Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells
title_fullStr	Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells
title_full_unstemmed	Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells
title_sort	opposing activities of oncogenic mir17hg and tumor suppressive mir100hg clusters and their gene targets regulate replicative senescence in human adult stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e3010ed26bd14b8ca45b854bb7cfd1b4
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Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells

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