Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy

Kimiko Shimizu,1 Yohei Hashimoto,1 Keiko Azuma,1 Yoko Nomura,1 Ryo Obata,1 Hidenori Takahashi,1,2 Yasuo Yanagi3,4 1Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, 2Department of Ophthalmology, Jichi Medical University, Tochigi, Japan; 3S...

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Autores principales:	Shimizu K, Hashimoto Y, Azuma K, Nomura Y, Obata R, Takahashi H, Yanagi Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	photodynamic therapy photoreceptor outer segment length chronic central serous chorioretinopathy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e302fe5401de4be5916a85e2e110c859
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spelling	oai:doaj.org-article:e302fe5401de4be5916a85e2e110c8592021-12-02T00:19:25ZChanges of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy1177-5483https://doaj.org/article/e302fe5401de4be5916a85e2e110c8592017-08-01T00:00:00Zhttps://www.dovepress.com/changes-of-outer-retinal-microstructures-after-photodynamic-therapy-fo-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kimiko Shimizu,1 Yohei Hashimoto,1 Keiko Azuma,1 Yoko Nomura,1 Ryo Obata,1 Hidenori Takahashi,1,2 Yasuo Yanagi3,4 1Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, 2Department of Ophthalmology, Jichi Medical University, Tochigi, Japan; 3Singapore Eye Research Institute, Singapore National Eye Center, 4Ophthalmology and Visual Sciences Program, Duke-NUS Medical School, National University of Singapore, Singapore Purpose: To evaluate the morphological changes in retinal microstructures following modified photodynamic therapy (PDT) for chronic central serous chorioretinopathy. Subjects and methods: Retrospective study of 21 consecutive eyes (age, 59±8.0 years [mean ± SD]) of 21 patients with chronic central serous chorioretinopathy. Inner foveal thickness (the distance between the internal limiting membrane and external limiting membrane), photoreceptor outer segment (PROS) length at the point without serous retinal detachment and choroidal thickness were assessed with enhanced depth imaging optical coherence tomography before treatment and at 1, 3 and 6 months after modified PDT. Results: Six eyes had half-dose and 15 eyes had half-fluence PDT. PROS length within the irradiated area was significantly decreased by 3.9% at 1 month compared with that before modified PDT (43.5±5.72 and 40.5±7.53, P=0.020 [paired t-test]) and returned to baseline length at 3 and 6 months (43.0±5.42 and 43.5±4.33 µm [mean ± SD]; P=0.53 and 1.00 [paired t-test]). PROS length of the nonirradiated area at 1, 3 and 6 months after modified PDT did not significantly differ from that before PDT (41.8±6.35, 41.4±5.33, 41.9±4.67 and 42.3±4.26 µm [mean ± SD]; P=0.66, 0.90 and 0.60, respectively [paired t-test]). There was no significant change in inner foveal thickness during the observation period. At all time points, choroidal thickness was significantly thinner than it was before PDT (P<0.001, paired t-test). Conclusion: Modified PDT may cause mild temporary microstructural changes. Keywords: photodynamic therapy, photoreceptor outer segment length, chronic central serous chorioretinopathy, inner foveal thickness, choriocapillarisShimizu KHashimoto YAzuma KNomura YObata RTakahashi HYanagi YDove Medical Pressarticlephotodynamic therapyphotoreceptor outer segment lengthchronic central serous chorioretinopathyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1505-1512 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	photodynamic therapy photoreceptor outer segment length chronic central serous chorioretinopathy Ophthalmology RE1-994
spellingShingle	photodynamic therapy photoreceptor outer segment length chronic central serous chorioretinopathy Ophthalmology RE1-994 Shimizu K Hashimoto Y Azuma K Nomura Y Obata R Takahashi H Yanagi Y Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
description	Kimiko Shimizu,1 Yohei Hashimoto,1 Keiko Azuma,1 Yoko Nomura,1 Ryo Obata,1 Hidenori Takahashi,1,2 Yasuo Yanagi3,4 1Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, 2Department of Ophthalmology, Jichi Medical University, Tochigi, Japan; 3Singapore Eye Research Institute, Singapore National Eye Center, 4Ophthalmology and Visual Sciences Program, Duke-NUS Medical School, National University of Singapore, Singapore Purpose: To evaluate the morphological changes in retinal microstructures following modified photodynamic therapy (PDT) for chronic central serous chorioretinopathy. Subjects and methods: Retrospective study of 21 consecutive eyes (age, 59±8.0 years [mean ± SD]) of 21 patients with chronic central serous chorioretinopathy. Inner foveal thickness (the distance between the internal limiting membrane and external limiting membrane), photoreceptor outer segment (PROS) length at the point without serous retinal detachment and choroidal thickness were assessed with enhanced depth imaging optical coherence tomography before treatment and at 1, 3 and 6 months after modified PDT. Results: Six eyes had half-dose and 15 eyes had half-fluence PDT. PROS length within the irradiated area was significantly decreased by 3.9% at 1 month compared with that before modified PDT (43.5±5.72 and 40.5±7.53, P=0.020 [paired t-test]) and returned to baseline length at 3 and 6 months (43.0±5.42 and 43.5±4.33 µm [mean ± SD]; P=0.53 and 1.00 [paired t-test]). PROS length of the nonirradiated area at 1, 3 and 6 months after modified PDT did not significantly differ from that before PDT (41.8±6.35, 41.4±5.33, 41.9±4.67 and 42.3±4.26 µm [mean ± SD]; P=0.66, 0.90 and 0.60, respectively [paired t-test]). There was no significant change in inner foveal thickness during the observation period. At all time points, choroidal thickness was significantly thinner than it was before PDT (P<0.001, paired t-test). Conclusion: Modified PDT may cause mild temporary microstructural changes. Keywords: photodynamic therapy, photoreceptor outer segment length, chronic central serous chorioretinopathy, inner foveal thickness, choriocapillaris
format	article
author	Shimizu K Hashimoto Y Azuma K Nomura Y Obata R Takahashi H Yanagi Y
author_facet	Shimizu K Hashimoto Y Azuma K Nomura Y Obata R Takahashi H Yanagi Y
author_sort	Shimizu K
title	Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
title_short	Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
title_full	Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
title_fullStr	Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
title_full_unstemmed	Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
title_sort	changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e302fe5401de4be5916a85e2e110c859
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Changes of outer retinal microstructures after photodynamic therapy for chronic central serous chorioretinopathy

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