The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts.
<h4>Objective</h4>To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART).<h4>Design</h4>Two large observational cohorts of HIV-infec...
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2013
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oai:doaj.org-article:e303afeb39704a84ab4101e6c4c3175a2021-11-18T07:53:49ZThe impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts.1932-620310.1371/journal.pone.0058812https://doaj.org/article/e303afeb39704a84ab4101e6c4c3175a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23554932/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART).<h4>Design</h4>Two large observational cohorts of HIV-infected and HIV-uninfected men (Multicenter AIDS Cohort Study [MACS]) and women (Women's Interagency HIV Study [WIHS]), followed since 1984 and 1994, respectively.<h4>Methods</h4>Adjusted odds or hazards ratios for incident respiratory infections or non-infectious respiratory diagnoses, respectively, in HIV-infected compared to HIV-uninfected individuals in both the pre-HAART (MACS only) and HAART eras; and adjusted Cox proportional hazard ratios for mortality in HIV-infected persons with lung disease during the HAART era.<h4>Results</h4>Compared to HIV-uninfected participants, HIV-infected individuals had more incident respiratory infections both pre-HAART (MACS, odds ratio [adjusted-OR], 2.4; 95% confidence interval [CI], 2.2-2.7; p<0.001) and after HAART availability (MACS, adjusted-OR, 1.5; 95%CI 1.3-1.7; p<0.001; WIHS adjusted-OR, 2.2; 95%CI 1.8-2.7; p<0.001). Chronic obstructive pulmonary disease was more common in MACS HIV-infected vs. HIV-uninfected participants pre-HAART (hazard ratio [adjusted-HR] 2.9; 95%CI, 1.02-8.4; p = 0.046). After HAART availability, non-infectious lung diseases were not significantly more common in HIV-infected participants in either MACS or WIHS participants. HIV-infected participants in the HAART era with respiratory infections had an increased risk of death compared to those without infections (MACS adjusted-HR, 1.5; 95%CI, 1.3-1.7; p<0.001; WIHS adjusted-HR, 1.9; 95%CI, 1.5-2.4; p<0.001).<h4>Conclusion</h4>HIV infection remained a significant risk for infectious respiratory diseases after the introduction of HAART, and infectious respiratory diseases were associated with an increased risk of mortality.Matthew R GingoG K BalasubramaniLawrence KingsleyCharles R RinaldoChristine B AldenRoger DetelsRuth M GreenblattNancy A HessolSusan HolmanLaurence HuangEric C KleerupJohn PhairSarah H SuttonEric C SeabergJoseph B MargolickStephen R WisniewskiAlison MorrisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58812 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Matthew R Gingo G K Balasubramani Lawrence Kingsley Charles R Rinaldo Christine B Alden Roger Detels Ruth M Greenblatt Nancy A Hessol Susan Holman Laurence Huang Eric C Kleerup John Phair Sarah H Sutton Eric C Seaberg Joseph B Margolick Stephen R Wisniewski Alison Morris The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. |
| description |
<h4>Objective</h4>To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART).<h4>Design</h4>Two large observational cohorts of HIV-infected and HIV-uninfected men (Multicenter AIDS Cohort Study [MACS]) and women (Women's Interagency HIV Study [WIHS]), followed since 1984 and 1994, respectively.<h4>Methods</h4>Adjusted odds or hazards ratios for incident respiratory infections or non-infectious respiratory diagnoses, respectively, in HIV-infected compared to HIV-uninfected individuals in both the pre-HAART (MACS only) and HAART eras; and adjusted Cox proportional hazard ratios for mortality in HIV-infected persons with lung disease during the HAART era.<h4>Results</h4>Compared to HIV-uninfected participants, HIV-infected individuals had more incident respiratory infections both pre-HAART (MACS, odds ratio [adjusted-OR], 2.4; 95% confidence interval [CI], 2.2-2.7; p<0.001) and after HAART availability (MACS, adjusted-OR, 1.5; 95%CI 1.3-1.7; p<0.001; WIHS adjusted-OR, 2.2; 95%CI 1.8-2.7; p<0.001). Chronic obstructive pulmonary disease was more common in MACS HIV-infected vs. HIV-uninfected participants pre-HAART (hazard ratio [adjusted-HR] 2.9; 95%CI, 1.02-8.4; p = 0.046). After HAART availability, non-infectious lung diseases were not significantly more common in HIV-infected participants in either MACS or WIHS participants. HIV-infected participants in the HAART era with respiratory infections had an increased risk of death compared to those without infections (MACS adjusted-HR, 1.5; 95%CI, 1.3-1.7; p<0.001; WIHS adjusted-HR, 1.9; 95%CI, 1.5-2.4; p<0.001).<h4>Conclusion</h4>HIV infection remained a significant risk for infectious respiratory diseases after the introduction of HAART, and infectious respiratory diseases were associated with an increased risk of mortality. |
| format |
article |
| author |
Matthew R Gingo G K Balasubramani Lawrence Kingsley Charles R Rinaldo Christine B Alden Roger Detels Ruth M Greenblatt Nancy A Hessol Susan Holman Laurence Huang Eric C Kleerup John Phair Sarah H Sutton Eric C Seaberg Joseph B Margolick Stephen R Wisniewski Alison Morris |
| author_facet |
Matthew R Gingo G K Balasubramani Lawrence Kingsley Charles R Rinaldo Christine B Alden Roger Detels Ruth M Greenblatt Nancy A Hessol Susan Holman Laurence Huang Eric C Kleerup John Phair Sarah H Sutton Eric C Seaberg Joseph B Margolick Stephen R Wisniewski Alison Morris |
| author_sort |
Matthew R Gingo |
| title |
The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. |
| title_short |
The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. |
| title_full |
The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. |
| title_fullStr |
The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. |
| title_full_unstemmed |
The impact of HAART on the respiratory complications of HIV infection: longitudinal trends in the MACS and WIHS cohorts. |
| title_sort |
impact of haart on the respiratory complications of hiv infection: longitudinal trends in the macs and wihs cohorts. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/e303afeb39704a84ab4101e6c4c3175a |
| work_keys_str_mv |
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