Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.

The Glaucoma Stereo Analysis Study (GSAS) is a multicenter collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. This study evaluated the retinal vessel calibers and correlations using GSAS fundus photographs between retinal vessels and 38 opt...

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Autores principales:	Kazunobu Sugihara, Yasuyuki Takai, Ryo Kawasaki, Koji Nitta, Maki Katai, Yasushi Kitaoka, Yu Yokoyama, Kazuko Omodaka, Tomoko Naito, Takehiro Yamashita, Shiro Mizoue, Aiko Iwase, Toru Nakazawa, Masaki Tanito
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e30460f51d644f048637bf8b4a4cc619
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spelling	oai:doaj.org-article:e30460f51d644f048637bf8b4a4cc6192021-12-02T20:04:47ZComparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.1932-620310.1371/journal.pone.0250245https://doaj.org/article/e30460f51d644f048637bf8b4a4cc6192021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0250245https://doaj.org/toc/1932-6203The Glaucoma Stereo Analysis Study (GSAS) is a multicenter collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. This study evaluated the retinal vessel calibers and correlations using GSAS fundus photographs between retinal vessels and 38 optic nerve head (ONH) morphologic parameters comprehensively. In all 240 eyes, the mean central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were 138.4 and 216.5 μm, respectively; the CRAE correlated with age, visual field scores and 19 ONH parameters and CRVE correlated with age, intraocular pressure, visual field scores and 11 ONH parameters. Among the different optic disc appearances including focal ischemia (FI) (n = 53, 22%), generalized enlargement (GE) (n = 53, 22%), myopic glaucoma (MY) (n = 112, 47%), and senile sclerosis (SS) (n = 22, 9%), the CRAE did not differ significantly; CRVE was significantly narrower in SS than in FI and MY. In FI, GE, MY, and SS disc types, CRAE correlated with 3, 14, 9, and 2 ONH parameters, respectively, and CRVE corelated with 9, 0, 12, and 6 ONH parameters, respectively. We confirmed previous observations on the effect of retinal vessel narrowing on glaucomatous changes in the ONH and visual field. The associations between retinal vessel caliber and ONH morphologic parameters vary among different optic disc appearances, suggesting different effects of vascular changes in each disc type.Kazunobu SugiharaYasuyuki TakaiRyo KawasakiKoji NittaMaki KataiYasushi KitaokaYu YokoyamaKazuko OmodakaTomoko NaitoTakehiro YamashitaShiro MizoueAiko IwaseToru NakazawaMasaki TanitoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0250245 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazunobu Sugihara Yasuyuki Takai Ryo Kawasaki Koji Nitta Maki Katai Yasushi Kitaoka Yu Yokoyama Kazuko Omodaka Tomoko Naito Takehiro Yamashita Shiro Mizoue Aiko Iwase Toru Nakazawa Masaki Tanito Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.
description	The Glaucoma Stereo Analysis Study (GSAS) is a multicenter collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. This study evaluated the retinal vessel calibers and correlations using GSAS fundus photographs between retinal vessels and 38 optic nerve head (ONH) morphologic parameters comprehensively. In all 240 eyes, the mean central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were 138.4 and 216.5 μm, respectively; the CRAE correlated with age, visual field scores and 19 ONH parameters and CRVE correlated with age, intraocular pressure, visual field scores and 11 ONH parameters. Among the different optic disc appearances including focal ischemia (FI) (n = 53, 22%), generalized enlargement (GE) (n = 53, 22%), myopic glaucoma (MY) (n = 112, 47%), and senile sclerosis (SS) (n = 22, 9%), the CRAE did not differ significantly; CRVE was significantly narrower in SS than in FI and MY. In FI, GE, MY, and SS disc types, CRAE correlated with 3, 14, 9, and 2 ONH parameters, respectively, and CRVE corelated with 9, 0, 12, and 6 ONH parameters, respectively. We confirmed previous observations on the effect of retinal vessel narrowing on glaucomatous changes in the ONH and visual field. The associations between retinal vessel caliber and ONH morphologic parameters vary among different optic disc appearances, suggesting different effects of vascular changes in each disc type.
format	article
author	Kazunobu Sugihara Yasuyuki Takai Ryo Kawasaki Koji Nitta Maki Katai Yasushi Kitaoka Yu Yokoyama Kazuko Omodaka Tomoko Naito Takehiro Yamashita Shiro Mizoue Aiko Iwase Toru Nakazawa Masaki Tanito
author_facet	Kazunobu Sugihara Yasuyuki Takai Ryo Kawasaki Koji Nitta Maki Katai Yasushi Kitaoka Yu Yokoyama Kazuko Omodaka Tomoko Naito Takehiro Yamashita Shiro Mizoue Aiko Iwase Toru Nakazawa Masaki Tanito
author_sort	Kazunobu Sugihara
title	Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.
title_short	Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.
title_full	Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.
title_fullStr	Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.
title_full_unstemmed	Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.
title_sort	comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: the glaucoma stereo analysis study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e30460f51d644f048637bf8b4a4cc619
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Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study.

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