Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.

<h4>Objective</h4>To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF.<h4>Methods</h4>Allelic association statistics were calculated f...

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Autores principales:	Russell Lewis McLaughlin, Julie Phukan, William McCormack, David S Lynch, Matthew Greenway, Simon Cronin, Jean Saunders, Agnieska Slowik, Barbara Tomik, Peter M Andersen, Daniel G Bradley, Phil Jakeman, Orla Hardiman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3048d6aaff64f5992df97bb9a6c23ad
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spelling	oai:doaj.org-article:e3048d6aaff64f5992df97bb9a6c23ad2021-11-18T07:36:59ZAngiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.1932-620310.1371/journal.pone.0015402https://doaj.org/article/e3048d6aaff64f5992df97bb9a6c23ad2010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21085671/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF.<h4>Methods</h4>Allelic association statistics were calculated for polymorphisms in the ANG gene in 859 patients and 1047 controls from Sweden, Ireland and Poland. Plasma, serum and CSF angiogenin levels were quantified and stratified according to genotypes across the ANG gene. The contribution of SNP genotypes to variance in circulating angiogenin levels was estimated in patients and controls.<h4>Results</h4>All SNPs showed association with ALS in the Irish group. The SNP rs17114699 replicated in the Swedish cohort. No SNP associated in the Polish cohort. Age- and sex-corrected circulating angiogenin levels were significantly lower in patients than in controls (p<0.001). An allele dose-dependent regulation of angiogenin levels was observed in controls. This regulation was attenuated in the ALS cohort. A significant positive correlation between CSF plasma angiogenin levels was present in controls and abolished in ALS.<h4>Conclusions</h4>ANG variants associate with ALS in the Irish and Swedish populations, but not in the Polish. There is evidence of dysregulation of angiogenin expression in plasma and CSF in sporadic ALS. Angiogenin expression is likely to be important in the pathogenesis of ALS.Russell Lewis McLaughlinJulie PhukanWilliam McCormackDavid S LynchMatthew GreenwaySimon CroninJean SaundersAgnieska SlowikBarbara TomikPeter M AndersenDaniel G BradleyPhil JakemanOrla HardimanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e15402 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Russell Lewis McLaughlin Julie Phukan William McCormack David S Lynch Matthew Greenway Simon Cronin Jean Saunders Agnieska Slowik Barbara Tomik Peter M Andersen Daniel G Bradley Phil Jakeman Orla Hardiman Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.
description	<h4>Objective</h4>To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF.<h4>Methods</h4>Allelic association statistics were calculated for polymorphisms in the ANG gene in 859 patients and 1047 controls from Sweden, Ireland and Poland. Plasma, serum and CSF angiogenin levels were quantified and stratified according to genotypes across the ANG gene. The contribution of SNP genotypes to variance in circulating angiogenin levels was estimated in patients and controls.<h4>Results</h4>All SNPs showed association with ALS in the Irish group. The SNP rs17114699 replicated in the Swedish cohort. No SNP associated in the Polish cohort. Age- and sex-corrected circulating angiogenin levels were significantly lower in patients than in controls (p<0.001). An allele dose-dependent regulation of angiogenin levels was observed in controls. This regulation was attenuated in the ALS cohort. A significant positive correlation between CSF plasma angiogenin levels was present in controls and abolished in ALS.<h4>Conclusions</h4>ANG variants associate with ALS in the Irish and Swedish populations, but not in the Polish. There is evidence of dysregulation of angiogenin expression in plasma and CSF in sporadic ALS. Angiogenin expression is likely to be important in the pathogenesis of ALS.
format	article
author	Russell Lewis McLaughlin Julie Phukan William McCormack David S Lynch Matthew Greenway Simon Cronin Jean Saunders Agnieska Slowik Barbara Tomik Peter M Andersen Daniel G Bradley Phil Jakeman Orla Hardiman
author_facet	Russell Lewis McLaughlin Julie Phukan William McCormack David S Lynch Matthew Greenway Simon Cronin Jean Saunders Agnieska Slowik Barbara Tomik Peter M Andersen Daniel G Bradley Phil Jakeman Orla Hardiman
author_sort	Russell Lewis McLaughlin
title	Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.
title_short	Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.
title_full	Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.
title_fullStr	Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.
title_full_unstemmed	Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.
title_sort	angiogenin levels and ang genotypes: dysregulation in amyotrophic lateral sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/e3048d6aaff64f5992df97bb9a6c23ad
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Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.

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