Mediator subunit 12 is required for neutrophil development in zebrafish.

Hematopoiesis requires the spatiotemporal organization of regulatory factors to successfully orchestrate diverse lineage specificity from stem and progenitor cells. Med12 is a regulatory component of the large Mediator complex that enables contact between the general RNA polymerase II transcriptiona...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria-Cristina Keightley, Judith E Layton, John W Hayman, Joan K Heath, Graham J Lieschke
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3049a45bf784fce84b80aff8f00f856
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e3049a45bf784fce84b80aff8f00f856
record_format	dspace
spelling	oai:doaj.org-article:e3049a45bf784fce84b80aff8f00f8562021-11-18T06:47:14ZMediator subunit 12 is required for neutrophil development in zebrafish.1932-620310.1371/journal.pone.0023845https://doaj.org/article/e3049a45bf784fce84b80aff8f00f8562011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21901140/?tool=EBIhttps://doaj.org/toc/1932-6203Hematopoiesis requires the spatiotemporal organization of regulatory factors to successfully orchestrate diverse lineage specificity from stem and progenitor cells. Med12 is a regulatory component of the large Mediator complex that enables contact between the general RNA polymerase II transcriptional machinery and enhancer bound regulatory factors. We have identified a new zebrafish med12 allele, syr, with a single missense mutation causing a valine to aspartic acid change at position 1046. Syr shows defects in hematopoiesis, which predominantly affect the myeloid lineage. Syr has identified a hematopoietic cell-specific requirement for Med12, suggesting a new role for this transcriptional regulator.Maria-Cristina KeightleyJudith E LaytonJohn W HaymanJoan K HeathGraham J LieschkePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23845 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria-Cristina Keightley Judith E Layton John W Hayman Joan K Heath Graham J Lieschke Mediator subunit 12 is required for neutrophil development in zebrafish.
description	Hematopoiesis requires the spatiotemporal organization of regulatory factors to successfully orchestrate diverse lineage specificity from stem and progenitor cells. Med12 is a regulatory component of the large Mediator complex that enables contact between the general RNA polymerase II transcriptional machinery and enhancer bound regulatory factors. We have identified a new zebrafish med12 allele, syr, with a single missense mutation causing a valine to aspartic acid change at position 1046. Syr shows defects in hematopoiesis, which predominantly affect the myeloid lineage. Syr has identified a hematopoietic cell-specific requirement for Med12, suggesting a new role for this transcriptional regulator.
format	article
author	Maria-Cristina Keightley Judith E Layton John W Hayman Joan K Heath Graham J Lieschke
author_facet	Maria-Cristina Keightley Judith E Layton John W Hayman Joan K Heath Graham J Lieschke
author_sort	Maria-Cristina Keightley
title	Mediator subunit 12 is required for neutrophil development in zebrafish.
title_short	Mediator subunit 12 is required for neutrophil development in zebrafish.
title_full	Mediator subunit 12 is required for neutrophil development in zebrafish.
title_fullStr	Mediator subunit 12 is required for neutrophil development in zebrafish.
title_full_unstemmed	Mediator subunit 12 is required for neutrophil development in zebrafish.
title_sort	mediator subunit 12 is required for neutrophil development in zebrafish.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e3049a45bf784fce84b80aff8f00f856
work_keys_str_mv	AT mariacristinakeightley mediatorsubunit12isrequiredforneutrophildevelopmentinzebrafish AT judithelayton mediatorsubunit12isrequiredforneutrophildevelopmentinzebrafish AT johnwhayman mediatorsubunit12isrequiredforneutrophildevelopmentinzebrafish AT joankheath mediatorsubunit12isrequiredforneutrophildevelopmentinzebrafish AT grahamjlieschke mediatorsubunit12isrequiredforneutrophildevelopmentinzebrafish
_version_	1718424450945253376

Mediator subunit 12 is required for neutrophil development in zebrafish.

Ejemplares similares