The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study

Abstract Background Most preterm infants require a continuous glucose infusion in the early postnatal period due to the interruption of the transplacental glucose supply after birth to promote better neurodevelopmental outcomes. Aims To investigate the glucose infusion rate (GIR) on parenteral nutri...

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Autores principales:	Dina Angelika, Risa Etika, Martono Tri Utomo, Setya Mirha, Kartika Darma Handayani, I. Dewa Gede Ugrasena
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Parenteral nutrition Glucose infusion rate Morbidity Mortality Preterm infant Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/e305613146084478869f1b402c9dc2f4
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spelling	oai:doaj.org-article:e305613146084478869f1b402c9dc2f42021-11-08T11:17:50ZThe glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study10.1186/s13052-021-01165-71824-7288https://doaj.org/article/e305613146084478869f1b402c9dc2f42021-11-01T00:00:00Zhttps://doi.org/10.1186/s13052-021-01165-7https://doaj.org/toc/1824-7288Abstract Background Most preterm infants require a continuous glucose infusion in the early postnatal period due to the interruption of the transplacental glucose supply after birth to promote better neurodevelopmental outcomes. Aims To investigate the glucose infusion rate (GIR) on parenteral nutrition (PN) in the first week of life administered in preterm infants and its effect on neonatal morbidity and mortality. Methods This study included 97 infants aged < 37 gestational weeks and weighed < 2500 g at birth. Infants recruited in this study were classified into 3 groups based on the GIR usage in parenteral nutrition as follows: GIR usage of 5- < 7 g/kg/day (Group I), GIR usage of 7–13 g/kg/day (Group II), and GIR usage of > 13–15 g/kg/day (Group III). Univariate and multivariate logistic regression analyzes were carried out to investigate whether the GIR usage in the three groups was associated with selected neonatal morbidities and mortality. Neonatal morbidities analyzed included respiratory distress syndrome (RDS), necrotizing enterocolitis, sepsis, retinopathy of prematurity, pulmonary hypertension, hypoglycemia, and hyperglycemia. Result Of 97 preterm infants included, 51.5% infants had a gestational age of 34- < 37 weeks, and 54.6% infants had a birth weight of 1500- < 2500 g. The multivariate logistic regression analysis showed that the GIR usage of 5- < 7 g/kg/day was an independent variable that significantly increased the risk of hypoglycemia (Adjusted Odds Ratio [AOR] = 4.000, 95% Confidence Interval [CI] = 1.384–11.565, P = 0.010) and reduced the risk of sepsis (AOR = 0.096, 95% CI = 0.012–0.757, P = 0.026). The GIR usage in all three groups did not increase the risk of mortality. For neonatal morbidity analyzed in this study, RDS (AOR = 5.404, 95%CI = 1.421–20.548, P = 0.013) was an independent risk factor of mortality. Conclusion The GIR usage of < 7 g/kg/day in PN in the first week of life administered to preterm infants was an independent variable in increasing hypoglycemia, but in contrast, reducing the risk of sepsis.Dina AngelikaRisa EtikaMartono Tri UtomoSetya MirhaKartika Darma HandayaniI. Dewa Gede UgrasenaBMCarticleParenteral nutritionGlucose infusion rateMorbidityMortalityPreterm infantPediatricsRJ1-570ENItalian Journal of Pediatrics, Vol 47, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parenteral nutrition Glucose infusion rate Morbidity Mortality Preterm infant Pediatrics RJ1-570
spellingShingle	Parenteral nutrition Glucose infusion rate Morbidity Mortality Preterm infant Pediatrics RJ1-570 Dina Angelika Risa Etika Martono Tri Utomo Setya Mirha Kartika Darma Handayani I. Dewa Gede Ugrasena The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study
description	Abstract Background Most preterm infants require a continuous glucose infusion in the early postnatal period due to the interruption of the transplacental glucose supply after birth to promote better neurodevelopmental outcomes. Aims To investigate the glucose infusion rate (GIR) on parenteral nutrition (PN) in the first week of life administered in preterm infants and its effect on neonatal morbidity and mortality. Methods This study included 97 infants aged < 37 gestational weeks and weighed < 2500 g at birth. Infants recruited in this study were classified into 3 groups based on the GIR usage in parenteral nutrition as follows: GIR usage of 5- < 7 g/kg/day (Group I), GIR usage of 7–13 g/kg/day (Group II), and GIR usage of > 13–15 g/kg/day (Group III). Univariate and multivariate logistic regression analyzes were carried out to investigate whether the GIR usage in the three groups was associated with selected neonatal morbidities and mortality. Neonatal morbidities analyzed included respiratory distress syndrome (RDS), necrotizing enterocolitis, sepsis, retinopathy of prematurity, pulmonary hypertension, hypoglycemia, and hyperglycemia. Result Of 97 preterm infants included, 51.5% infants had a gestational age of 34- < 37 weeks, and 54.6% infants had a birth weight of 1500- < 2500 g. The multivariate logistic regression analysis showed that the GIR usage of 5- < 7 g/kg/day was an independent variable that significantly increased the risk of hypoglycemia (Adjusted Odds Ratio [AOR] = 4.000, 95% Confidence Interval [CI] = 1.384–11.565, P = 0.010) and reduced the risk of sepsis (AOR = 0.096, 95% CI = 0.012–0.757, P = 0.026). The GIR usage in all three groups did not increase the risk of mortality. For neonatal morbidity analyzed in this study, RDS (AOR = 5.404, 95%CI = 1.421–20.548, P = 0.013) was an independent risk factor of mortality. Conclusion The GIR usage of < 7 g/kg/day in PN in the first week of life administered to preterm infants was an independent variable in increasing hypoglycemia, but in contrast, reducing the risk of sepsis.
format	article
author	Dina Angelika Risa Etika Martono Tri Utomo Setya Mirha Kartika Darma Handayani I. Dewa Gede Ugrasena
author_facet	Dina Angelika Risa Etika Martono Tri Utomo Setya Mirha Kartika Darma Handayani I. Dewa Gede Ugrasena
author_sort	Dina Angelika
title	The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study
title_short	The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study
title_full	The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study
title_fullStr	The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study
title_full_unstemmed	The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study
title_sort	glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e305613146084478869f1b402c9dc2f4
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The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study

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