Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo

Protein delivery with cell-penetrating peptides suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting treatment success. Here the authors present an intracellular protein delivery system and demonstrate efficient delivery in vitro and therapeutic efficacy in a liver...

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Autores principales:	Siyuan Yu, Han Yang, Tingdong Li, Haifeng Pan, Shuling Ren, Guoxing Luo, Jinlu Jiang, Linqi Yu, Binbing Chen, Yali Zhang, Shaojuan Wang, Rui Tian, Tianying Zhang, Shiyin Zhang, Yixin Chen, Quan Yuan, Shengxiang Ge, Jun Zhang, Ningshao Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e30762d64de74ddb83def6a74c94fb19
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spelling	oai:doaj.org-article:e30762d64de74ddb83def6a74c94fb192021-12-02T15:09:10ZEfficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo10.1038/s41467-021-25448-z2041-1723https://doaj.org/article/e30762d64de74ddb83def6a74c94fb192021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25448-zhttps://doaj.org/toc/2041-1723Protein delivery with cell-penetrating peptides suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting treatment success. Here the authors present an intracellular protein delivery system and demonstrate efficient delivery in vitro and therapeutic efficacy in a liver failure model in vivo.Siyuan YuHan YangTingdong LiHaifeng PanShuling RenGuoxing LuoJinlu JiangLinqi YuBinbing ChenYali ZhangShaojuan WangRui TianTianying ZhangShiyin ZhangYixin ChenQuan YuanShengxiang GeJun ZhangNingshao XiaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siyuan Yu Han Yang Tingdong Li Haifeng Pan Shuling Ren Guoxing Luo Jinlu Jiang Linqi Yu Binbing Chen Yali Zhang Shaojuan Wang Rui Tian Tianying Zhang Shiyin Zhang Yixin Chen Quan Yuan Shengxiang Ge Jun Zhang Ningshao Xia Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
description	Protein delivery with cell-penetrating peptides suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting treatment success. Here the authors present an intracellular protein delivery system and demonstrate efficient delivery in vitro and therapeutic efficacy in a liver failure model in vivo.
format	article
author	Siyuan Yu Han Yang Tingdong Li Haifeng Pan Shuling Ren Guoxing Luo Jinlu Jiang Linqi Yu Binbing Chen Yali Zhang Shaojuan Wang Rui Tian Tianying Zhang Shiyin Zhang Yixin Chen Quan Yuan Shengxiang Ge Jun Zhang Ningshao Xia
author_facet	Siyuan Yu Han Yang Tingdong Li Haifeng Pan Shuling Ren Guoxing Luo Jinlu Jiang Linqi Yu Binbing Chen Yali Zhang Shaojuan Wang Rui Tian Tianying Zhang Shiyin Zhang Yixin Chen Quan Yuan Shengxiang Ge Jun Zhang Ningshao Xia
author_sort	Siyuan Yu
title	Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
title_short	Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
title_full	Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
title_fullStr	Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
title_full_unstemmed	Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
title_sort	efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e30762d64de74ddb83def6a74c94fb19
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Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo

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