Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise

Abstract This study aimed to evaluate muscle oxidative function during exercise in amyotrophic lateral sclerosis patients (pALS) with non-invasive methods in order to assess if determinants of reduced exercise tolerance might match ALS clinical heterogeneity. 17 pALS, who were followed for 4 months,...

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Autores principales:	F. Lanfranconi, A. Ferri, G. Corna, R. Bonazzi, C. Lunetta, V. Silani, N. Riva, A. Rigamonti, A. Maggiani, C. Ferrarese, L. Tremolizzo
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Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e3097b9394be4f758c3a41c4f7e01355
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spelling	oai:doaj.org-article:e3097b9394be4f758c3a41c4f7e013552021-12-02T15:05:48ZInefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise10.1038/s41598-017-02811-z2045-2322https://doaj.org/article/e3097b9394be4f758c3a41c4f7e013552017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02811-zhttps://doaj.org/toc/2045-2322Abstract This study aimed to evaluate muscle oxidative function during exercise in amyotrophic lateral sclerosis patients (pALS) with non-invasive methods in order to assess if determinants of reduced exercise tolerance might match ALS clinical heterogeneity. 17 pALS, who were followed for 4 months, were compared with 13 healthy controls (CTRL). Exercise tolerance was assessed by an incremental exercise test on cycle ergometer measuring peak O2 uptake ( $$\dot{{\rm{V}}}$$ V ̇ O2peak), vastus lateralis oxidative function by near infrared spectroscopy (NIRS) and breathing pattern ( $$\dot{{\rm{V}}}$$ V ̇ E peak). pALS displayed: (1) 44% lower $$\dot{{\rm{V}}}$$ V ̇ O2peak vs. CTRL (p < 0.0001), paralleled by a 43% decreased peak skeletal muscle oxidative function (p < 0.01), with a linear regression between these two variables (r2 = 0.64, p < 0.0001); (2) 46% reduced $$\dot{{\rm{V}}}$$ V ̇ Epeak vs. CTRL (p < 0.0001), achieved by using an inefficient breathing pattern (increasing respiratory frequency) from the onset until the end of exercise. Inefficient skeletal muscle O2 function, when flanking the impaired motor units recruitment, is a major determinant of pALS clinical heterogeneity and working capacity exercise tolerance. CPET and NIRS are useful tools for detecting early stages of oxidative deficiency in skeletal muscles, disclosing individual impairments in the O2 transport and utilization chain.F. LanfranconiA. FerriG. CornaR. BonazziC. LunettaV. SilaniN. RivaA. RigamontiA. MaggianiC. FerrareseL. TremolizzoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Lanfranconi A. Ferri G. Corna R. Bonazzi C. Lunetta V. Silani N. Riva A. Rigamonti A. Maggiani C. Ferrarese L. Tremolizzo Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise
description	Abstract This study aimed to evaluate muscle oxidative function during exercise in amyotrophic lateral sclerosis patients (pALS) with non-invasive methods in order to assess if determinants of reduced exercise tolerance might match ALS clinical heterogeneity. 17 pALS, who were followed for 4 months, were compared with 13 healthy controls (CTRL). Exercise tolerance was assessed by an incremental exercise test on cycle ergometer measuring peak O2 uptake ( $$\dot{{\rm{V}}}$$ V ̇ O2peak), vastus lateralis oxidative function by near infrared spectroscopy (NIRS) and breathing pattern ( $$\dot{{\rm{V}}}$$ V ̇ E peak). pALS displayed: (1) 44% lower $$\dot{{\rm{V}}}$$ V ̇ O2peak vs. CTRL (p < 0.0001), paralleled by a 43% decreased peak skeletal muscle oxidative function (p < 0.01), with a linear regression between these two variables (r2 = 0.64, p < 0.0001); (2) 46% reduced $$\dot{{\rm{V}}}$$ V ̇ Epeak vs. CTRL (p < 0.0001), achieved by using an inefficient breathing pattern (increasing respiratory frequency) from the onset until the end of exercise. Inefficient skeletal muscle O2 function, when flanking the impaired motor units recruitment, is a major determinant of pALS clinical heterogeneity and working capacity exercise tolerance. CPET and NIRS are useful tools for detecting early stages of oxidative deficiency in skeletal muscles, disclosing individual impairments in the O2 transport and utilization chain.
format	article
author	F. Lanfranconi A. Ferri G. Corna R. Bonazzi C. Lunetta V. Silani N. Riva A. Rigamonti A. Maggiani C. Ferrarese L. Tremolizzo
author_facet	F. Lanfranconi A. Ferri G. Corna R. Bonazzi C. Lunetta V. Silani N. Riva A. Rigamonti A. Maggiani C. Ferrarese L. Tremolizzo
author_sort	F. Lanfranconi
title	Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise
title_short	Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise
title_full	Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise
title_fullStr	Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise
title_full_unstemmed	Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise
title_sort	inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in amyotrophic lateral sclerosis during exercise
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e3097b9394be4f758c3a41c4f7e01355
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Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise

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