Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys

Abstract Population-level ecological studies show type 1 diabetes incidence is inversely correlated with ambient ultraviolet radiation (UVR) levels. We conducted a nested case–control study using administrative datasets to test this association at the individual level. Cases (n = 1819) were children...

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Autores principales:	Kate M. Miller, Prue H. Hart, Robyn M. Lucas, Elizabeth A. Davis, Nicholas H. de Klerk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e30b9cd7c63045df98b30a22affbaa99
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spelling	oai:doaj.org-article:e30b9cd7c63045df98b30a22affbaa992021-12-02T17:26:49ZHigher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys10.1038/s41598-021-97469-z2045-2322https://doaj.org/article/e30b9cd7c63045df98b30a22affbaa992021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97469-zhttps://doaj.org/toc/2045-2322Abstract Population-level ecological studies show type 1 diabetes incidence is inversely correlated with ambient ultraviolet radiation (UVR) levels. We conducted a nested case–control study using administrative datasets to test this association at the individual level. Cases (n = 1819) were children born in Western Australia (WA) from 1980–2014, diagnosed with type 1 diabetes at ≤ 16 years. Controls (n = 27,259) were randomly selected from all live births in WA, matched to cases by sex and date of birth. Total ambient erythemal ultraviolet radiation (UVR) doses for each trimester of pregnancy and first year of life were estimated for each individual, using daily NASA satellite data that were date- and geographically-specific. Conditional logistic regression tested the association between UVR dose and case–control status. Type 1 diabetes risk was 42% lower in boys of mothers with third-trimester UVR dose in the highest (compared to the lowest) quartile (p = 0.04). Higher UVR in the first year of life was associated with lower type 1 diabetes risk among boys (p = 0.01). UVR dose was not associated with type 1 diabetes risk in girls. Higher UVR in late pregnancy and early life appear to interact with sex-specific factors to lower type 1 diabetes risk among boys in Western Australia.Kate M. MillerPrue H. HartRobyn M. LucasElizabeth A. DavisNicholas H. de KlerkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kate M. Miller Prue H. Hart Robyn M. Lucas Elizabeth A. Davis Nicholas H. de Klerk Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys
description	Abstract Population-level ecological studies show type 1 diabetes incidence is inversely correlated with ambient ultraviolet radiation (UVR) levels. We conducted a nested case–control study using administrative datasets to test this association at the individual level. Cases (n = 1819) were children born in Western Australia (WA) from 1980–2014, diagnosed with type 1 diabetes at ≤ 16 years. Controls (n = 27,259) were randomly selected from all live births in WA, matched to cases by sex and date of birth. Total ambient erythemal ultraviolet radiation (UVR) doses for each trimester of pregnancy and first year of life were estimated for each individual, using daily NASA satellite data that were date- and geographically-specific. Conditional logistic regression tested the association between UVR dose and case–control status. Type 1 diabetes risk was 42% lower in boys of mothers with third-trimester UVR dose in the highest (compared to the lowest) quartile (p = 0.04). Higher UVR in the first year of life was associated with lower type 1 diabetes risk among boys (p = 0.01). UVR dose was not associated with type 1 diabetes risk in girls. Higher UVR in late pregnancy and early life appear to interact with sex-specific factors to lower type 1 diabetes risk among boys in Western Australia.
format	article
author	Kate M. Miller Prue H. Hart Robyn M. Lucas Elizabeth A. Davis Nicholas H. de Klerk
author_facet	Kate M. Miller Prue H. Hart Robyn M. Lucas Elizabeth A. Davis Nicholas H. de Klerk
author_sort	Kate M. Miller
title	Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys
title_short	Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys
title_full	Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys
title_fullStr	Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys
title_full_unstemmed	Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys
title_sort	higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e30b9cd7c63045df98b30a22affbaa99
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Higher ultraviolet radiation during early life is associated with lower risk of childhood type 1 diabetes among boys

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