HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns

The authors have previously shown that membrane voltage can influence embryonic patterning during development. Here, the authors computationally model how nicotine disrupts Xenopus embryogenesis by perturbing voltage gradients, and rescue nicotine-inducted defects with HCN2 channel expression.

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Autores principales:	Vaibhav P. Pai, Alexis Pietak, Valerie Willocq, Bin Ye, Nian-Qing Shi, Michael Levin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e30cbd3fc0a9494ba626b09310562894
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spelling	oai:doaj.org-article:e30cbd3fc0a9494ba626b093105628942021-12-02T15:34:37ZHCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns10.1038/s41467-018-03334-52041-1723https://doaj.org/article/e30cbd3fc0a9494ba626b093105628942018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03334-5https://doaj.org/toc/2041-1723The authors have previously shown that membrane voltage can influence embryonic patterning during development. Here, the authors computationally model how nicotine disrupts Xenopus embryogenesis by perturbing voltage gradients, and rescue nicotine-inducted defects with HCN2 channel expression.Vaibhav P. PaiAlexis PietakValerie WillocqBin YeNian-Qing ShiMichael LevinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vaibhav P. Pai Alexis Pietak Valerie Willocq Bin Ye Nian-Qing Shi Michael Levin HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
description	The authors have previously shown that membrane voltage can influence embryonic patterning during development. Here, the authors computationally model how nicotine disrupts Xenopus embryogenesis by perturbing voltage gradients, and rescue nicotine-inducted defects with HCN2 channel expression.
format	article
author	Vaibhav P. Pai Alexis Pietak Valerie Willocq Bin Ye Nian-Qing Shi Michael Levin
author_facet	Vaibhav P. Pai Alexis Pietak Valerie Willocq Bin Ye Nian-Qing Shi Michael Levin
author_sort	Vaibhav P. Pai
title	HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
title_short	HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
title_full	HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
title_fullStr	HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
title_full_unstemmed	HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
title_sort	hcn2 rescues brain defects by enforcing endogenous voltage pre-patterns
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e30cbd3fc0a9494ba626b09310562894
work_keys_str_mv	AT vaibhavppai hcn2rescuesbraindefectsbyenforcingendogenousvoltageprepatterns AT alexispietak hcn2rescuesbraindefectsbyenforcingendogenousvoltageprepatterns AT valeriewillocq hcn2rescuesbraindefectsbyenforcingendogenousvoltageprepatterns AT binye hcn2rescuesbraindefectsbyenforcingendogenousvoltageprepatterns AT nianqingshi hcn2rescuesbraindefectsbyenforcingendogenousvoltageprepatterns AT michaellevin hcn2rescuesbraindefectsbyenforcingendogenousvoltageprepatterns
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HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns

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