Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation

Timothy Syndrome (TS) is a multisystem disorder caused by two mutations leading to dysfunction of the CaV1.2 channel. Here, Dick et al. uncover a major and mechanistically divergent effect of both mutations on Ca2+/calmodulin-dependent inactivation of CaV1.2 channels, suggesting genetic variant-tail...

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Autores principales: Ivy E. Dick, Rosy Joshi-Mukherjee, Wanjun Yang, David T. Yue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/e30e38494b244ba9928aab1ec875756a
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