Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation
Timothy Syndrome (TS) is a multisystem disorder caused by two mutations leading to dysfunction of the CaV1.2 channel. Here, Dick et al. uncover a major and mechanistically divergent effect of both mutations on Ca2+/calmodulin-dependent inactivation of CaV1.2 channels, suggesting genetic variant-tail...
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Autores principales: | Ivy E. Dick, Rosy Joshi-Mukherjee, Wanjun Yang, David T. Yue |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
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Materias: | |
Acceso en línea: | https://doaj.org/article/e30e38494b244ba9928aab1ec875756a |
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