Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

The host super elongation complex (SEC) is hijacked by HIV-1 for viral transcription. Here the authors present the structure of RNA polymerase elongation factor ELL2 bound to the intrinsically disordered scaffold protein AFF4, identifying an ELL2 surface important for HIV-1 transcription.

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Autores principales:	Shiqian Qi, Zichong Li, Ursula Schulze-Gahmen, Goran Stjepanovic, Qiang Zhou, James H. Hurley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e30f66ef897f4bb8982ba67f0e094f26
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spelling	oai:doaj.org-article:e30f66ef897f4bb8982ba67f0e094f262021-12-02T15:39:06ZStructural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription10.1038/ncomms140762041-1723https://doaj.org/article/e30f66ef897f4bb8982ba67f0e094f262017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14076https://doaj.org/toc/2041-1723The host super elongation complex (SEC) is hijacked by HIV-1 for viral transcription. Here the authors present the structure of RNA polymerase elongation factor ELL2 bound to the intrinsically disordered scaffold protein AFF4, identifying an ELL2 surface important for HIV-1 transcription.Shiqian QiZichong LiUrsula Schulze-GahmenGoran StjepanovicQiang ZhouJames H. HurleyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shiqian Qi Zichong Li Ursula Schulze-Gahmen Goran Stjepanovic Qiang Zhou James H. Hurley Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
description	The host super elongation complex (SEC) is hijacked by HIV-1 for viral transcription. Here the authors present the structure of RNA polymerase elongation factor ELL2 bound to the intrinsically disordered scaffold protein AFF4, identifying an ELL2 surface important for HIV-1 transcription.
format	article
author	Shiqian Qi Zichong Li Ursula Schulze-Gahmen Goran Stjepanovic Qiang Zhou James H. Hurley
author_facet	Shiqian Qi Zichong Li Ursula Schulze-Gahmen Goran Stjepanovic Qiang Zhou James H. Hurley
author_sort	Shiqian Qi
title	Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
title_short	Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
title_full	Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
title_fullStr	Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
title_full_unstemmed	Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
title_sort	structural basis for ell2 and aff4 activation of hiv-1 proviral transcription
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e30f66ef897f4bb8982ba67f0e094f26
work_keys_str_mv	AT shiqianqi structuralbasisforell2andaff4activationofhiv1proviraltranscription AT zichongli structuralbasisforell2andaff4activationofhiv1proviraltranscription AT ursulaschulzegahmen structuralbasisforell2andaff4activationofhiv1proviraltranscription AT goranstjepanovic structuralbasisforell2andaff4activationofhiv1proviraltranscription AT qiangzhou structuralbasisforell2andaff4activationofhiv1proviraltranscription AT jameshhurley structuralbasisforell2andaff4activationofhiv1proviraltranscription
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Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

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