Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription

The host super elongation complex (SEC) is hijacked by HIV-1 for viral transcription. Here the authors present the structure of RNA polymerase elongation factor ELL2 bound to the intrinsically disordered scaffold protein AFF4, identifying an ELL2 surface important for HIV-1 transcription.

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Autores principales: Shiqian Qi, Zichong Li, Ursula Schulze-Gahmen, Goran Stjepanovic, Qiang Zhou, James H. Hurley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e30f66ef897f4bb8982ba67f0e094f26
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