Enzymatic one-step ring contraction for quinolone biosynthesis

Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.

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Autores principales:	Shinji Kishimoto, Kodai Hara, Hiroshi Hashimoto, Yuichiro Hirayama, Pier Alexandre Champagne, Kendall N. Houk, Yi Tang, Kenji Watanabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e314b137eb8e447180aa93d7b1b86b62
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spelling	oai:doaj.org-article:e314b137eb8e447180aa93d7b1b86b622021-12-02T17:32:48ZEnzymatic one-step ring contraction for quinolone biosynthesis10.1038/s41467-018-05221-52041-1723https://doaj.org/article/e314b137eb8e447180aa93d7b1b86b622018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05221-5https://doaj.org/toc/2041-1723Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.Shinji KishimotoKodai HaraHiroshi HashimotoYuichiro HirayamaPier Alexandre ChampagneKendall N. HoukYi TangKenji WatanabeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shinji Kishimoto Kodai Hara Hiroshi Hashimoto Yuichiro Hirayama Pier Alexandre Champagne Kendall N. Houk Yi Tang Kenji Watanabe Enzymatic one-step ring contraction for quinolone biosynthesis
description	Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.
format	article
author	Shinji Kishimoto Kodai Hara Hiroshi Hashimoto Yuichiro Hirayama Pier Alexandre Champagne Kendall N. Houk Yi Tang Kenji Watanabe
author_facet	Shinji Kishimoto Kodai Hara Hiroshi Hashimoto Yuichiro Hirayama Pier Alexandre Champagne Kendall N. Houk Yi Tang Kenji Watanabe
author_sort	Shinji Kishimoto
title	Enzymatic one-step ring contraction for quinolone biosynthesis
title_short	Enzymatic one-step ring contraction for quinolone biosynthesis
title_full	Enzymatic one-step ring contraction for quinolone biosynthesis
title_fullStr	Enzymatic one-step ring contraction for quinolone biosynthesis
title_full_unstemmed	Enzymatic one-step ring contraction for quinolone biosynthesis
title_sort	enzymatic one-step ring contraction for quinolone biosynthesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e314b137eb8e447180aa93d7b1b86b62
work_keys_str_mv	AT shinjikishimoto enzymaticonestepringcontractionforquinolonebiosynthesis AT kodaihara enzymaticonestepringcontractionforquinolonebiosynthesis AT hiroshihashimoto enzymaticonestepringcontractionforquinolonebiosynthesis AT yuichirohirayama enzymaticonestepringcontractionforquinolonebiosynthesis AT pieralexandrechampagne enzymaticonestepringcontractionforquinolonebiosynthesis AT kendallnhouk enzymaticonestepringcontractionforquinolonebiosynthesis AT yitang enzymaticonestepringcontractionforquinolonebiosynthesis AT kenjiwatanabe enzymaticonestepringcontractionforquinolonebiosynthesis
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Enzymatic one-step ring contraction for quinolone biosynthesis

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