Endothelial keratoplasty with infant donor tissue

Akira Kobayashi, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Abstract: Here we report a case of endothelial keratoplasty with infant donor tissue obtained after brain d...

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Autores principales:	Kobayashi A, Yokogawa H, Yamazaki N, Masaki T, Sugiyama K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e31555a01f9d44e98febca1b427bec83
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spelling	oai:doaj.org-article:e31555a01f9d44e98febca1b427bec832021-12-02T02:48:18ZEndothelial keratoplasty with infant donor tissue1177-5483https://doaj.org/article/e31555a01f9d44e98febca1b427bec832014-09-01T00:00:00Zhttp://www.dovepress.com/endothelial-keratoplasty-with-infant-donor-tissue-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Akira Kobayashi, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Abstract: Here we report a case of endothelial keratoplasty with infant donor tissue obtained after brain death. A 52-year-old man with endothelial dysfunction of unknown cause in the right eye underwent non-Descemet stripping automated endothelial keratoplasty (nDSAEK) with tissue from an infant donor (2 years). Intraoperative and postoperative complications were recorded. Best corrected visual acuity and donor central endothelial cell density were recorded preoperatively and postoperatively. Infant donor tissue preparation with a microkeratome set at 300 µm was successful; the donor tissue was extremely elastic and soft compared with adult tissue. The central endothelial cell density of the infant donor tissue was as high as 4,291 cells/mm2. No complications were observed during donor tissue (8.0 mm in diameter) insertion with the double-glide technique (Busin glide with intraocular lens sheet glide) or any of the other procedures. Best corrected visual acuity improved from 1.7 logMAR (logarithm of the minimum angle of resolution; 0.02 decimal visual acuity) preoperatively to 0.2 logMAR (0.6) after 6 months and 0.1 logMAR (0.8) after 1 year. The central endothelial cell density after 6 months was 4,098 cells/mm2 (representing a 4.5% cell loss from preoperative donor cell measurements), and the central endothelial cell density after 1 year was 4,032 cells/mm2 (6.0% decrease). Infant donor tissue may be preferably used for DSAEK/nDASEK, since it may not be suitable for penetrating keratoplasty or Descemet membrane endothelial keratoplasty. Keywords: brain death, non-Descemet stripping automated endothelial keratoplasty, infant donor, endothelial keratoplastyKobayashi AYokogawa HYamazaki NMasaki TSugiyama KDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1827-1830 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kobayashi A Yokogawa H Yamazaki N Masaki T Sugiyama K Endothelial keratoplasty with infant donor tissue
description	Akira Kobayashi, Hideaki Yokogawa, Natsuko Yamazaki, Toshinori Masaki, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Abstract: Here we report a case of endothelial keratoplasty with infant donor tissue obtained after brain death. A 52-year-old man with endothelial dysfunction of unknown cause in the right eye underwent non-Descemet stripping automated endothelial keratoplasty (nDSAEK) with tissue from an infant donor (2 years). Intraoperative and postoperative complications were recorded. Best corrected visual acuity and donor central endothelial cell density were recorded preoperatively and postoperatively. Infant donor tissue preparation with a microkeratome set at 300 µm was successful; the donor tissue was extremely elastic and soft compared with adult tissue. The central endothelial cell density of the infant donor tissue was as high as 4,291 cells/mm2. No complications were observed during donor tissue (8.0 mm in diameter) insertion with the double-glide technique (Busin glide with intraocular lens sheet glide) or any of the other procedures. Best corrected visual acuity improved from 1.7 logMAR (logarithm of the minimum angle of resolution; 0.02 decimal visual acuity) preoperatively to 0.2 logMAR (0.6) after 6 months and 0.1 logMAR (0.8) after 1 year. The central endothelial cell density after 6 months was 4,098 cells/mm2 (representing a 4.5% cell loss from preoperative donor cell measurements), and the central endothelial cell density after 1 year was 4,032 cells/mm2 (6.0% decrease). Infant donor tissue may be preferably used for DSAEK/nDASEK, since it may not be suitable for penetrating keratoplasty or Descemet membrane endothelial keratoplasty. Keywords: brain death, non-Descemet stripping automated endothelial keratoplasty, infant donor, endothelial keratoplasty
format	article
author	Kobayashi A Yokogawa H Yamazaki N Masaki T Sugiyama K
author_facet	Kobayashi A Yokogawa H Yamazaki N Masaki T Sugiyama K
author_sort	Kobayashi A
title	Endothelial keratoplasty with infant donor tissue
title_short	Endothelial keratoplasty with infant donor tissue
title_full	Endothelial keratoplasty with infant donor tissue
title_fullStr	Endothelial keratoplasty with infant donor tissue
title_full_unstemmed	Endothelial keratoplasty with infant donor tissue
title_sort	endothelial keratoplasty with infant donor tissue
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/e31555a01f9d44e98febca1b427bec83
work_keys_str_mv	AT kobayashia endothelialkeratoplastywithinfantdonortissue AT yokogawah endothelialkeratoplastywithinfantdonortissue AT yamazakin endothelialkeratoplastywithinfantdonortissue AT masakit endothelialkeratoplastywithinfantdonortissue AT sugiyamak endothelialkeratoplastywithinfantdonortissue
_version_	1718402194228641792

Endothelial keratoplasty with infant donor tissue

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