Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects

Abstract Background The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might include some nuclear transport genes in D...

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Autores principales:	Ayda Mirsalehi, Dragomira N. Markova, Mohammadmehdi Eslamieh, Esther Betrán
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Nuclear transport Recurrent gene duplication Gene turnover Genetic conflict Drosophila Biotechnology TP248.13-248.65 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/e3158f1f2cea44a391e67bdd9ab539c3
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spelling	oai:doaj.org-article:e3158f1f2cea44a391e67bdd9ab539c32021-12-05T12:17:15ZNuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects10.1186/s12864-021-08170-41471-2164https://doaj.org/article/e3158f1f2cea44a391e67bdd9ab539c32021-12-01T00:00:00Zhttps://doi.org/10.1186/s12864-021-08170-4https://doaj.org/toc/1471-2164Abstract Background The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might include some nuclear transport genes in Drosophila. So, using a comprehensive, detailed phylogenomic study, we examined 51 insect genomes for the duplication of the same nuclear transport genes. Results We find that most of the nuclear transport duplications in Drosophila are of a few classes of nuclear transport genes, RNA mediated and fast evolving. We also retrieve many pseudogenes for the Ran gene. Some of the duplicates are relatively young and likely contributing to the turnover expected for genes under strong but changing selective pressures. These duplications are potentially revealing what features of nuclear transport are under selection. Unlike in flies, we find only a few duplications when we study the Drosophila duplicated nuclear transport genes in dipteran species outside of Drosophila, and none in other insects. Conclusions These findings strengthen the hypothesis that nuclear transport gene duplicates in Drosophila evolve either as drivers or suppressors of meiotic drive systems or as other male-specific adaptations circumscribed to flies and involving a handful of nuclear transport functions.Ayda MirsalehiDragomira N. MarkovaMohammadmehdi EslamiehEsther BetránBMCarticleNuclear transportRecurrent gene duplicationGene turnoverGenetic conflictDrosophilaBiotechnologyTP248.13-248.65GeneticsQH426-470ENBMC Genomics, Vol 22, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nuclear transport Recurrent gene duplication Gene turnover Genetic conflict Drosophila Biotechnology TP248.13-248.65 Genetics QH426-470
spellingShingle	Nuclear transport Recurrent gene duplication Gene turnover Genetic conflict Drosophila Biotechnology TP248.13-248.65 Genetics QH426-470 Ayda Mirsalehi Dragomira N. Markova Mohammadmehdi Eslamieh Esther Betrán Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
description	Abstract Background The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might include some nuclear transport genes in Drosophila. So, using a comprehensive, detailed phylogenomic study, we examined 51 insect genomes for the duplication of the same nuclear transport genes. Results We find that most of the nuclear transport duplications in Drosophila are of a few classes of nuclear transport genes, RNA mediated and fast evolving. We also retrieve many pseudogenes for the Ran gene. Some of the duplicates are relatively young and likely contributing to the turnover expected for genes under strong but changing selective pressures. These duplications are potentially revealing what features of nuclear transport are under selection. Unlike in flies, we find only a few duplications when we study the Drosophila duplicated nuclear transport genes in dipteran species outside of Drosophila, and none in other insects. Conclusions These findings strengthen the hypothesis that nuclear transport gene duplicates in Drosophila evolve either as drivers or suppressors of meiotic drive systems or as other male-specific adaptations circumscribed to flies and involving a handful of nuclear transport functions.
format	article
author	Ayda Mirsalehi Dragomira N. Markova Mohammadmehdi Eslamieh Esther Betrán
author_facet	Ayda Mirsalehi Dragomira N. Markova Mohammadmehdi Eslamieh Esther Betrán
author_sort	Ayda Mirsalehi
title	Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
title_short	Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
title_full	Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
title_fullStr	Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
title_full_unstemmed	Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
title_sort	nuclear transport genes recurrently duplicate by means of rna intermediates in drosophila but not in other insects
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e3158f1f2cea44a391e67bdd9ab539c3
work_keys_str_mv	AT aydamirsalehi nucleartransportgenesrecurrentlyduplicatebymeansofrnaintermediatesindrosophilabutnotinotherinsects AT dragomiranmarkova nucleartransportgenesrecurrentlyduplicatebymeansofrnaintermediatesindrosophilabutnotinotherinsects AT mohammadmehdieslamieh nucleartransportgenesrecurrentlyduplicatebymeansofrnaintermediatesindrosophilabutnotinotherinsects AT estherbetran nucleartransportgenesrecurrentlyduplicatebymeansofrnaintermediatesindrosophilabutnotinotherinsects
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Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects

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