The essential role of PRAK in tumor metastasis and its therapeutic potential

The essential role of PRAK in tumor metastasis and its therapeutic potential

Metastasis is one of the leading causes of cancer-related death. Here, the authors report a pro-metastatic role of PRAK in breast cancer lung metastasis via a mechanism involving enhanced HIF-1α translation, and propose PRAK targeting as a strategy to treat metastasis.

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Autores principales: Yuqing Wang, Wei Wang, Haoming Wu, Yu Zhou, Xiaodan Qin, Yan Wang, Jia Wu, Xiu-Yuan Sun, Yan Yang, Hui Xu, Xiaoping Qian, Xuewen Pang, Yan Li, Zhiqian Zhang, Jiahuai Han, Yu Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e316bbbf766c4207a4ac09e31608be76
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spelling oai:doaj.org-article:e316bbbf766c4207a4ac09e31608be762021-12-02T17:04:54ZThe essential role of PRAK in tumor metastasis and its therapeutic potential10.1038/s41467-021-21993-92041-1723https://doaj.org/article/e316bbbf766c4207a4ac09e31608be762021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21993-9https://doaj.org/toc/2041-1723Metastasis is one of the leading causes of cancer-related death. Here, the authors report a pro-metastatic role of PRAK in breast cancer lung metastasis via a mechanism involving enhanced HIF-1α translation, and propose PRAK targeting as a strategy to treat metastasis.Yuqing WangWei WangHaoming WuYu ZhouXiaodan QinYan WangJia WuXiu-Yuan SunYan YangHui XuXiaoping QianXuewen PangYan LiZhiqian ZhangJiahuai HanYu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuqing Wang
Wei Wang
Haoming Wu
Yu Zhou
Xiaodan Qin
Yan Wang
Jia Wu
Xiu-Yuan Sun
Yan Yang
Hui Xu
Xiaoping Qian
Xuewen Pang
Yan Li
Zhiqian Zhang
Jiahuai Han
Yu Zhang
The essential role of PRAK in tumor metastasis and its therapeutic potential
description Metastasis is one of the leading causes of cancer-related death. Here, the authors report a pro-metastatic role of PRAK in breast cancer lung metastasis via a mechanism involving enhanced HIF-1α translation, and propose PRAK targeting as a strategy to treat metastasis.
format article
author Yuqing Wang
Wei Wang
Haoming Wu
Yu Zhou
Xiaodan Qin
Yan Wang
Jia Wu
Xiu-Yuan Sun
Yan Yang
Hui Xu
Xiaoping Qian
Xuewen Pang
Yan Li
Zhiqian Zhang
Jiahuai Han
Yu Zhang
author_facet Yuqing Wang
Wei Wang
Haoming Wu
Yu Zhou
Xiaodan Qin
Yan Wang
Jia Wu
Xiu-Yuan Sun
Yan Yang
Hui Xu
Xiaoping Qian
Xuewen Pang
Yan Li
Zhiqian Zhang
Jiahuai Han
Yu Zhang
author_sort Yuqing Wang
title The essential role of PRAK in tumor metastasis and its therapeutic potential
title_short The essential role of PRAK in tumor metastasis and its therapeutic potential
title_full The essential role of PRAK in tumor metastasis and its therapeutic potential
title_fullStr The essential role of PRAK in tumor metastasis and its therapeutic potential
title_full_unstemmed The essential role of PRAK in tumor metastasis and its therapeutic potential
title_sort essential role of prak in tumor metastasis and its therapeutic potential
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e316bbbf766c4207a4ac09e31608be76
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