Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide, and hydrogen peroxide mediated oxidative stress has been implicated in liver injury. Here, the authors report the development of an anti-AQP3 monoclonal antibody, which alleviates liver injury in multiple mouse models.

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Autores principales:	Mariko Hara-Chikuma, Manami Tanaka, Alan S. Verkman, Masato Yasui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e318202226c44321ab0d1805baa94b42
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spelling	oai:doaj.org-article:e318202226c44321ab0d1805baa94b422021-12-02T15:34:13ZInhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury10.1038/s41467-020-19491-52041-1723https://doaj.org/article/e318202226c44321ab0d1805baa94b422020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19491-5https://doaj.org/toc/2041-1723Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide, and hydrogen peroxide mediated oxidative stress has been implicated in liver injury. Here, the authors report the development of an anti-AQP3 monoclonal antibody, which alleviates liver injury in multiple mouse models.Mariko Hara-ChikumaManami TanakaAlan S. VerkmanMasato YasuiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariko Hara-Chikuma Manami Tanaka Alan S. Verkman Masato Yasui Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
description	Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide, and hydrogen peroxide mediated oxidative stress has been implicated in liver injury. Here, the authors report the development of an anti-AQP3 monoclonal antibody, which alleviates liver injury in multiple mouse models.
format	article
author	Mariko Hara-Chikuma Manami Tanaka Alan S. Verkman Masato Yasui
author_facet	Mariko Hara-Chikuma Manami Tanaka Alan S. Verkman Masato Yasui
author_sort	Mariko Hara-Chikuma
title	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_short	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_full	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_fullStr	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_full_unstemmed	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_sort	inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e318202226c44321ab0d1805baa94b42
work_keys_str_mv	AT marikoharachikuma inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury AT manamitanaka inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury AT alansverkman inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury AT masatoyasui inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury
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Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

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