A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection

A risk factor for invasive Candida albicans infection is the use of broad-spectrum antibiotics, but the reasons are poorly understood. Here, the authors show in mice that β-lactam antibiotics cause commensal bacteria to release peptidoglycan fragments that induce the invasive hyphal growth of C. alb...

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Autores principales:	Chew Teng Tan, Xiaoli Xu, Yuan Qiao, Yue Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e31bee1739e8429c8500bdd1fa3fe068
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spelling	oai:doaj.org-article:e31bee1739e8429c8500bdd1fa3fe0682021-12-02T16:51:30ZA peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection10.1038/s41467-021-22845-22041-1723https://doaj.org/article/e31bee1739e8429c8500bdd1fa3fe0682021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22845-2https://doaj.org/toc/2041-1723A risk factor for invasive Candida albicans infection is the use of broad-spectrum antibiotics, but the reasons are poorly understood. Here, the authors show in mice that β-lactam antibiotics cause commensal bacteria to release peptidoglycan fragments that induce the invasive hyphal growth of C. albicans, leading to systemic dissemination.Chew Teng TanXiaoli XuYuan QiaoYue WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chew Teng Tan Xiaoli Xu Yuan Qiao Yue Wang A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection
description	A risk factor for invasive Candida albicans infection is the use of broad-spectrum antibiotics, but the reasons are poorly understood. Here, the authors show in mice that β-lactam antibiotics cause commensal bacteria to release peptidoglycan fragments that induce the invasive hyphal growth of C. albicans, leading to systemic dissemination.
format	article
author	Chew Teng Tan Xiaoli Xu Yuan Qiao Yue Wang
author_facet	Chew Teng Tan Xiaoli Xu Yuan Qiao Yue Wang
author_sort	Chew Teng Tan
title	A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection
title_short	A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection
title_full	A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection
title_fullStr	A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection
title_full_unstemmed	A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection
title_sort	peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives candida albicans infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e31bee1739e8429c8500bdd1fa3fe068
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A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection

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