Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

The exclusion of T cells from solid tumours is a potentially important mechanism that regulates whether or not cancer patients respond well to checkpoint blocking immunotherapies. Here the authors identify immune phenotypes and mediators of T cell exclusion among ovarian cancer patient samples from...

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Autores principales:	Mélanie Desbois, Akshata R. Udyavar, Lisa Ryner, Cleopatra Kozlowski, Yinghui Guan, Milena Dürrbaum, Shan Lu, Jean-Philippe Fortin, Hartmut Koeppen, James Ziai, Ching-Wei Chang, Shilpa Keerthivasan, Marie Plante, Richard Bourgon, Carlos Bais, Priti Hegde, Anneleen Daemen, Shannon Turley, Yulei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e31d51185c324442b45c5107128325ef
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spelling	oai:doaj.org-article:e31d51185c324442b45c5107128325ef2021-12-02T15:39:08ZIntegrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer10.1038/s41467-020-19408-22041-1723https://doaj.org/article/e31d51185c324442b45c5107128325ef2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19408-2https://doaj.org/toc/2041-1723The exclusion of T cells from solid tumours is a potentially important mechanism that regulates whether or not cancer patients respond well to checkpoint blocking immunotherapies. Here the authors identify immune phenotypes and mediators of T cell exclusion among ovarian cancer patient samples from the ICON7 phase III trial.Mélanie DesboisAkshata R. UdyavarLisa RynerCleopatra KozlowskiYinghui GuanMilena DürrbaumShan LuJean-Philippe FortinHartmut KoeppenJames ZiaiChing-Wei ChangShilpa KeerthivasanMarie PlanteRichard BourgonCarlos BaisPriti HegdeAnneleen DaemenShannon TurleyYulei WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mélanie Desbois Akshata R. Udyavar Lisa Ryner Cleopatra Kozlowski Yinghui Guan Milena Dürrbaum Shan Lu Jean-Philippe Fortin Hartmut Koeppen James Ziai Ching-Wei Chang Shilpa Keerthivasan Marie Plante Richard Bourgon Carlos Bais Priti Hegde Anneleen Daemen Shannon Turley Yulei Wang Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
description	The exclusion of T cells from solid tumours is a potentially important mechanism that regulates whether or not cancer patients respond well to checkpoint blocking immunotherapies. Here the authors identify immune phenotypes and mediators of T cell exclusion among ovarian cancer patient samples from the ICON7 phase III trial.
format	article
author	Mélanie Desbois Akshata R. Udyavar Lisa Ryner Cleopatra Kozlowski Yinghui Guan Milena Dürrbaum Shan Lu Jean-Philippe Fortin Hartmut Koeppen James Ziai Ching-Wei Chang Shilpa Keerthivasan Marie Plante Richard Bourgon Carlos Bais Priti Hegde Anneleen Daemen Shannon Turley Yulei Wang
author_facet	Mélanie Desbois Akshata R. Udyavar Lisa Ryner Cleopatra Kozlowski Yinghui Guan Milena Dürrbaum Shan Lu Jean-Philippe Fortin Hartmut Koeppen James Ziai Ching-Wei Chang Shilpa Keerthivasan Marie Plante Richard Bourgon Carlos Bais Priti Hegde Anneleen Daemen Shannon Turley Yulei Wang
author_sort	Mélanie Desbois
title	Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
title_short	Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
title_full	Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
title_fullStr	Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
title_full_unstemmed	Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer
title_sort	integrated digital pathology and transcriptome analysis identifies molecular mediators of t-cell exclusion in ovarian cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e31d51185c324442b45c5107128325ef
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Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer

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