Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity

Leishmaniasis is a tropical disease caused by parasites of the genus Leishmania spp; it presents different clinical manifestations, of which cutaneous leishmaniasis is the most common form, and it is endemic in more than 70 countries worldwide. Only four drugs are registered for the treatment of the...

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Autores principales:	Jorge Higuita-Castro, Iván D. Vélez, Diana M. Escobar, Javier Murillo, Tatiana Pineda, Victoria Ospina, Sara M. Robledo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cutaneous leishmaniasis Plant extracts Leishmanicidal activity Drug release kinetics In vitro assays In vivo studies Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/e3207489cef647789f04466d3db7679c
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spelling	oai:doaj.org-article:e3207489cef647789f04466d3db7679c2021-11-12T04:24:42ZDevelopment of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity0264-127510.1016/j.matdes.2021.110232https://doaj.org/article/e3207489cef647789f04466d3db7679c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0264127521007875https://doaj.org/toc/0264-1275Leishmaniasis is a tropical disease caused by parasites of the genus Leishmania spp; it presents different clinical manifestations, of which cutaneous leishmaniasis is the most common form, and it is endemic in more than 70 countries worldwide. Only four drugs are registered for the treatment of the disease, all associated with high toxicity. Recently, the in vitro and in vivo leishmanicidal activity of a mixture of the benzoic acid 2-(2,3-dihydro-4H-1-benzopyran-4-ylidene) hydrazide (TC2) and the compounds present in the plant extract Sapindus saponaria L (SS) were reported. In the present study were prepared soft capsules of chitosan incorporating TC2 and SS in 1:1 (CQ) ratio showed low cytotoxicity in U937 macrophages but moderate cytotoxicity in Detroit 551 fibroblast and had high antileishmanial activity against intracellular L. braziliensis amastigotes. The kinetics of TC2 release from CQ was fitted to the Korsmeyer-Peppas model. Finally, CQ was effective in treating experimental cutaneous leishmaniasis induced in the hamster model. In conclusion, the CQ are biocompatible and can help treat cutaneous leishmaniasis.Jorge Higuita-CastroIván D. VélezDiana M. EscobarJavier MurilloTatiana PinedaVictoria OspinaSara M. RobledoElsevierarticleCutaneous leishmaniasisPlant extractsLeishmanicidal activityDrug release kineticsIn vitro assaysIn vivo studiesMaterials of engineering and construction. Mechanics of materialsTA401-492ENMaterials & Design, Vol 212, Iss , Pp 110232- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cutaneous leishmaniasis Plant extracts Leishmanicidal activity Drug release kinetics In vitro assays In vivo studies Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Cutaneous leishmaniasis Plant extracts Leishmanicidal activity Drug release kinetics In vitro assays In vivo studies Materials of engineering and construction. Mechanics of materials TA401-492 Jorge Higuita-Castro Iván D. Vélez Diana M. Escobar Javier Murillo Tatiana Pineda Victoria Ospina Sara M. Robledo Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity
description	Leishmaniasis is a tropical disease caused by parasites of the genus Leishmania spp; it presents different clinical manifestations, of which cutaneous leishmaniasis is the most common form, and it is endemic in more than 70 countries worldwide. Only four drugs are registered for the treatment of the disease, all associated with high toxicity. Recently, the in vitro and in vivo leishmanicidal activity of a mixture of the benzoic acid 2-(2,3-dihydro-4H-1-benzopyran-4-ylidene) hydrazide (TC2) and the compounds present in the plant extract Sapindus saponaria L (SS) were reported. In the present study were prepared soft capsules of chitosan incorporating TC2 and SS in 1:1 (CQ) ratio showed low cytotoxicity in U937 macrophages but moderate cytotoxicity in Detroit 551 fibroblast and had high antileishmanial activity against intracellular L. braziliensis amastigotes. The kinetics of TC2 release from CQ was fitted to the Korsmeyer-Peppas model. Finally, CQ was effective in treating experimental cutaneous leishmaniasis induced in the hamster model. In conclusion, the CQ are biocompatible and can help treat cutaneous leishmaniasis.
format	article
author	Jorge Higuita-Castro Iván D. Vélez Diana M. Escobar Javier Murillo Tatiana Pineda Victoria Ospina Sara M. Robledo
author_facet	Jorge Higuita-Castro Iván D. Vélez Diana M. Escobar Javier Murillo Tatiana Pineda Victoria Ospina Sara M. Robledo
author_sort	Jorge Higuita-Castro
title	Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity
title_short	Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity
title_full	Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity
title_fullStr	Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity
title_full_unstemmed	Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity
title_sort	development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e3207489cef647789f04466d3db7679c
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Development of a biocompatible polymeric chitosan system for the release of compounds with leishmanicidal activity

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