17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

Variations in the 17q21 locus are linked to asthma susceptibility and other autoimmune diseases. Here, the authors perform cell type-specific functional genomic analyses of asthma-risk SNPs, and show a genotype specific mechanism of differential gene regulation relevant to immune function.

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Autores principales: Benjamin Joachim Schmiedel, Grégory Seumois, Daniela Samaniego-Castruita, Justin Cayford, Veronique Schulten, Lukas Chavez, Ferhat Ay, Alessandro Sette, Bjoern Peters, Pandurangan Vijayanand
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/e3236bb261ed40f88943e91e159bc89e
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spelling oai:doaj.org-article:e3236bb261ed40f88943e91e159bc89e2021-12-02T14:39:31Z17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells10.1038/ncomms134262041-1723https://doaj.org/article/e3236bb261ed40f88943e91e159bc89e2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13426https://doaj.org/toc/2041-1723Variations in the 17q21 locus are linked to asthma susceptibility and other autoimmune diseases. Here, the authors perform cell type-specific functional genomic analyses of asthma-risk SNPs, and show a genotype specific mechanism of differential gene regulation relevant to immune function.Benjamin Joachim SchmiedelGrégory SeumoisDaniela Samaniego-CastruitaJustin CayfordVeronique SchultenLukas ChavezFerhat AyAlessandro SetteBjoern PetersPandurangan VijayanandNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Benjamin Joachim Schmiedel
Grégory Seumois
Daniela Samaniego-Castruita
Justin Cayford
Veronique Schulten
Lukas Chavez
Ferhat Ay
Alessandro Sette
Bjoern Peters
Pandurangan Vijayanand
17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
description Variations in the 17q21 locus are linked to asthma susceptibility and other autoimmune diseases. Here, the authors perform cell type-specific functional genomic analyses of asthma-risk SNPs, and show a genotype specific mechanism of differential gene regulation relevant to immune function.
format article
author Benjamin Joachim Schmiedel
Grégory Seumois
Daniela Samaniego-Castruita
Justin Cayford
Veronique Schulten
Lukas Chavez
Ferhat Ay
Alessandro Sette
Bjoern Peters
Pandurangan Vijayanand
author_facet Benjamin Joachim Schmiedel
Grégory Seumois
Daniela Samaniego-Castruita
Justin Cayford
Veronique Schulten
Lukas Chavez
Ferhat Ay
Alessandro Sette
Bjoern Peters
Pandurangan Vijayanand
author_sort Benjamin Joachim Schmiedel
title 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
title_short 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
title_full 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
title_fullStr 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
title_full_unstemmed 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
title_sort 17q21 asthma-risk variants switch ctcf binding and regulate il-2 production by t cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/e3236bb261ed40f88943e91e159bc89e
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AT danielasamaniegocastruita 17q21asthmariskvariantsswitchctcfbindingandregulateil2productionbytcells
AT justincayford 17q21asthmariskvariantsswitchctcfbindingandregulateil2productionbytcells
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