Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages

STAT1a is required for pro-inflammatory responses in macrophages. Here the authors reveal that post-translational modification of STAT1a, ADPribosylation, plays a critical role in enhancer formation and activation, thus modulating IFNγ-stimulated inflammatory responses in macrophages.

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Detalles Bibliográficos
Autores principales:	Rebecca Gupte, Tulip Nandu, W. Lee Kraus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e323c3b056fa45c286ff54b1c4102557
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spelling	oai:doaj.org-article:e323c3b056fa45c286ff54b1c41025572021-12-02T17:12:24ZNuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages10.1038/s41467-021-24225-22041-1723https://doaj.org/article/e323c3b056fa45c286ff54b1c41025572021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24225-2https://doaj.org/toc/2041-1723STAT1a is required for pro-inflammatory responses in macrophages. Here the authors reveal that post-translational modification of STAT1a, ADPribosylation, plays a critical role in enhancer formation and activation, thus modulating IFNγ-stimulated inflammatory responses in macrophages.Rebecca GupteTulip NanduW. Lee KrausNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Gupte Tulip Nandu W. Lee Kraus Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages
description	STAT1a is required for pro-inflammatory responses in macrophages. Here the authors reveal that post-translational modification of STAT1a, ADPribosylation, plays a critical role in enhancer formation and activation, thus modulating IFNγ-stimulated inflammatory responses in macrophages.
format	article
author	Rebecca Gupte Tulip Nandu W. Lee Kraus
author_facet	Rebecca Gupte Tulip Nandu W. Lee Kraus
author_sort	Rebecca Gupte
title	Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages
title_short	Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages
title_full	Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages
title_fullStr	Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages
title_full_unstemmed	Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages
title_sort	nuclear adp-ribosylation drives ifnγ-dependent stat1α enhancer formation in macrophages
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e323c3b056fa45c286ff54b1c4102557
work_keys_str_mv	AT rebeccagupte nuclearadpribosylationdrivesifngdependentstat1aenhancerformationinmacrophages AT tulipnandu nuclearadpribosylationdrivesifngdependentstat1aenhancerformationinmacrophages AT wleekraus nuclearadpribosylationdrivesifngdependentstat1aenhancerformationinmacrophages
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Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages

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