Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

Physical activity is increasingly recognized as a strategy able to improve cancer patient outcome, and its potential to enhance treatment response is promising, despite being unclear. In our study we used a preclinical model of prostate cancer to investigate whether voluntary wheel running (VWR) cou...

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Autores principales:	Suzanne Dufresne, Cindy Richard, Arthur Dieumegard, Luz Orfila, Gregory Delpon, Sophie Chiavassa, Brice Martin, Laurent Rouvière, Jean-Michel Escoffre, Edward Oujagir, Baudouin Denis de Senneville, Ayache Bouakaz, Nathalie Rioux-Leclercq, Vincent Potiron, Amélie Rébillard
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	physical activity exercise prostate cancer radiotherapy radiation therapy vascularization Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e3247b800d5741a78d371b8534109d85
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spelling	oai:doaj.org-article:e3247b800d5741a78d371b8534109d852021-11-11T15:30:18ZVoluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?10.3390/cancers132154022072-6694https://doaj.org/article/e3247b800d5741a78d371b8534109d852021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5402https://doaj.org/toc/2072-6694Physical activity is increasingly recognized as a strategy able to improve cancer patient outcome, and its potential to enhance treatment response is promising, despite being unclear. In our study we used a preclinical model of prostate cancer to investigate whether voluntary wheel running (VWR) could improve tumor perfusion and enhance radiotherapy (RT) efficiency. Nude athymic mice were injected with PC-3 cancer cells and either remained inactive or were housed with running wheels. Apparent microbubble transport was enhanced with VWR, which we hypothesized could improve the RT response. When repeating the experiments and adding RT, however, we observed that VWR did not influence RT efficiency. These findings contrasted with previous results and prompted us to evaluate if the lack of effects observed on tumor growth could be attributable to the physical activity modality used. Using PC-3 and PPC-1 xenografts, we randomized mice to either inactive controls, VWR, or treadmill running (TR). In both models, TR (but not VWR) slowed down tumor growth, suggesting that the anti-cancer effects of physical activity are dependent on its modalities. Providing a better understanding of which activity type should be recommended to cancer patients thus appears essential to improve treatment outcomes.Suzanne DufresneCindy RichardArthur DieumegardLuz OrfilaGregory DelponSophie ChiavassaBrice MartinLaurent RouvièreJean-Michel EscoffreEdward OujagirBaudouin Denis de SennevilleAyache BouakazNathalie Rioux-LeclercqVincent PotironAmélie RébillardMDPI AGarticlephysical activityexerciseprostate cancerradiotherapyradiation therapyvascularizationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5402, p 5402 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	physical activity exercise prostate cancer radiotherapy radiation therapy vascularization Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	physical activity exercise prostate cancer radiotherapy radiation therapy vascularization Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Suzanne Dufresne Cindy Richard Arthur Dieumegard Luz Orfila Gregory Delpon Sophie Chiavassa Brice Martin Laurent Rouvière Jean-Michel Escoffre Edward Oujagir Baudouin Denis de Senneville Ayache Bouakaz Nathalie Rioux-Leclercq Vincent Potiron Amélie Rébillard Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?
description	Physical activity is increasingly recognized as a strategy able to improve cancer patient outcome, and its potential to enhance treatment response is promising, despite being unclear. In our study we used a preclinical model of prostate cancer to investigate whether voluntary wheel running (VWR) could improve tumor perfusion and enhance radiotherapy (RT) efficiency. Nude athymic mice were injected with PC-3 cancer cells and either remained inactive or were housed with running wheels. Apparent microbubble transport was enhanced with VWR, which we hypothesized could improve the RT response. When repeating the experiments and adding RT, however, we observed that VWR did not influence RT efficiency. These findings contrasted with previous results and prompted us to evaluate if the lack of effects observed on tumor growth could be attributable to the physical activity modality used. Using PC-3 and PPC-1 xenografts, we randomized mice to either inactive controls, VWR, or treadmill running (TR). In both models, TR (but not VWR) slowed down tumor growth, suggesting that the anti-cancer effects of physical activity are dependent on its modalities. Providing a better understanding of which activity type should be recommended to cancer patients thus appears essential to improve treatment outcomes.
format	article
author	Suzanne Dufresne Cindy Richard Arthur Dieumegard Luz Orfila Gregory Delpon Sophie Chiavassa Brice Martin Laurent Rouvière Jean-Michel Escoffre Edward Oujagir Baudouin Denis de Senneville Ayache Bouakaz Nathalie Rioux-Leclercq Vincent Potiron Amélie Rébillard
author_facet	Suzanne Dufresne Cindy Richard Arthur Dieumegard Luz Orfila Gregory Delpon Sophie Chiavassa Brice Martin Laurent Rouvière Jean-Michel Escoffre Edward Oujagir Baudouin Denis de Senneville Ayache Bouakaz Nathalie Rioux-Leclercq Vincent Potiron Amélie Rébillard
author_sort	Suzanne Dufresne
title	Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?
title_short	Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?
title_full	Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?
title_fullStr	Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?
title_full_unstemmed	Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?
title_sort	voluntary wheel running does not enhance radiotherapy efficiency in a preclinical model of prostate cancer: the importance of physical activity modalities?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e3247b800d5741a78d371b8534109d85
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Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

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