Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots

Seshadri Reddy Ankireddy, Jongsung Kim Department of Chemical and Biological Engineering, Gachon University, Seongnam, South Korea Abstract: Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, s...

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Autores principales:	Ankireddy SR, Kim J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e3257e38e6014ec9997eb2b8231c12ec
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spelling	oai:doaj.org-article:e3257e38e6014ec9997eb2b8231c12ec2021-12-02T03:05:15ZSelective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots1178-2013https://doaj.org/article/e3257e38e6014ec9997eb2b8231c12ec2015-08-01T00:00:00Zhttp://www.dovepress.com/selective-detection-of-dopamine-in-the-presence-of-ascorbic-acid-via-f-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Seshadri Reddy Ankireddy, Jongsung Kim Department of Chemical and Biological Engineering, Gachon University, Seongnam, South Korea Abstract: Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, such as Parkinson’s disease, attention deficit hyperactivity disorder, restless legs syndrome, are believed to be related to deficiency of dopamine. Several studies have been performed to detect dopamine by using electrochemical analysis. In this study, quantum dots (QDs) were used as sensing media for the detection of dopamine. The surface of the QDs was modified with L-cysteine by coupling reaction to increase the selectivity of dopamine. The fluorescence of cysteine-capped indium phosphide/zinc sulfide QDs was quenched by dopamine with various concentrations in the presence of ascorbic acid. This method shows good selectivity for dopamine detection, and the detection limit was 5 nM. Keywords: InP/ZnS QDs, Parkinson’s disease, L-dopamine, ascorbic acid, neurotransmitter, photoluminescenceAnkireddy SRKim JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 113-119 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ankireddy SR Kim J Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots
description	Seshadri Reddy Ankireddy, Jongsung Kim Department of Chemical and Biological Engineering, Gachon University, Seongnam, South Korea Abstract: Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, such as Parkinson’s disease, attention deficit hyperactivity disorder, restless legs syndrome, are believed to be related to deficiency of dopamine. Several studies have been performed to detect dopamine by using electrochemical analysis. In this study, quantum dots (QDs) were used as sensing media for the detection of dopamine. The surface of the QDs was modified with L-cysteine by coupling reaction to increase the selectivity of dopamine. The fluorescence of cysteine-capped indium phosphide/zinc sulfide QDs was quenched by dopamine with various concentrations in the presence of ascorbic acid. This method shows good selectivity for dopamine detection, and the detection limit was 5 nM. Keywords: InP/ZnS QDs, Parkinson’s disease, L-dopamine, ascorbic acid, neurotransmitter, photoluminescence
format	article
author	Ankireddy SR Kim J
author_facet	Ankireddy SR Kim J
author_sort	Ankireddy SR
title	Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots
title_short	Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots
title_full	Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots
title_fullStr	Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots
title_full_unstemmed	Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots
title_sort	selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of inp/zns quantum dots
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e3257e38e6014ec9997eb2b8231c12ec
work_keys_str_mv	AT ankireddysr selectivedetectionofdopamineinthepresenceofascorbicacidviafluorescencequenchingofinpznsquantumdots AT kimj selectivedetectionofdopamineinthepresenceofascorbicacidviafluorescencequenchingofinpznsquantumdots
_version_	1718402013149003776

Selective detection of dopamine in the presence of ascorbic acid via fluorescence quenching of InP/ZnS quantum dots

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