Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin

Dreier et al. reports that the anion channelrhodopsin GtACR1 does not undergo a syn-cycle (light adapted ground state) and thus has a more efficient channel behaviour than CrChR2. They propose that constructing variants lacking syn-cycle could optimize channelrhodopsin for optogenetic applications.

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Autores principales:	Max-Aylmer Dreier, Philipp Althoff, Mohamad Javad Norahan, Stefan Alexander Tennigkeit, Samir F. El-Mashtoly, Mathias Lübben, Carsten Kötting, Till Rudack, Klaus Gerwert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e32a077ee10e427a92017a371359e82d
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spelling	oai:doaj.org-article:e32a077ee10e427a92017a371359e82d2021-12-02T15:43:17ZTime-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin10.1038/s42003-021-02101-52399-3642https://doaj.org/article/e32a077ee10e427a92017a371359e82d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02101-5https://doaj.org/toc/2399-3642Dreier et al. reports that the anion channelrhodopsin GtACR1 does not undergo a syn-cycle (light adapted ground state) and thus has a more efficient channel behaviour than CrChR2. They propose that constructing variants lacking syn-cycle could optimize channelrhodopsin for optogenetic applications.Max-Aylmer DreierPhilipp AlthoffMohamad Javad NorahanStefan Alexander TennigkeitSamir F. El-MashtolyMathias LübbenCarsten KöttingTill RudackKlaus GerwertNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Max-Aylmer Dreier Philipp Althoff Mohamad Javad Norahan Stefan Alexander Tennigkeit Samir F. El-Mashtoly Mathias Lübben Carsten Kötting Till Rudack Klaus Gerwert Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
description	Dreier et al. reports that the anion channelrhodopsin GtACR1 does not undergo a syn-cycle (light adapted ground state) and thus has a more efficient channel behaviour than CrChR2. They propose that constructing variants lacking syn-cycle could optimize channelrhodopsin for optogenetic applications.
format	article
author	Max-Aylmer Dreier Philipp Althoff Mohamad Javad Norahan Stefan Alexander Tennigkeit Samir F. El-Mashtoly Mathias Lübben Carsten Kötting Till Rudack Klaus Gerwert
author_facet	Max-Aylmer Dreier Philipp Althoff Mohamad Javad Norahan Stefan Alexander Tennigkeit Samir F. El-Mashtoly Mathias Lübben Carsten Kötting Till Rudack Klaus Gerwert
author_sort	Max-Aylmer Dreier
title	Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
title_short	Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
title_full	Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
title_fullStr	Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
title_full_unstemmed	Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
title_sort	time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e32a077ee10e427a92017a371359e82d
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Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin

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