Anti-tumor activity of a miR-199-dependent oncolytic adenovirus.

Anti-tumor activity of a miR-199-dependent oncolytic adenovirus.

The down-regulation of miR-199 occurs in nearly all primary hepatocellular carcinomas (HCCs) and HCC cell lines in comparison with normal liver. We exploited this miR-199 differential expression to develop a conditionally replication-competent oncolytic adenovirus, Ad-199T, and achieve tumor-specifi...

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Autores principales: Elisa Callegari, Bahaeldin K Elamin, Lucilla D'Abundo, Simonetta Falzoni, Giovanna Donvito, Farzaneh Moshiri, Maddalena Milazzo, Giuseppe Altavilla, Luciano Giacomelli, Francesca Fornari, Akseli Hemminki, Francesco Di Virgilio, Laura Gramantieri, Massimo Negrini, Silvia Sabbioni
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e32ca045d1634705983595653fa456a4
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