OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS

Abstract. A new role of B-cells in pathogenesis of multiple sclerosis (MS), their relations with B-cells indevelopment of inflammation and probable mechanisms of advanced therapeutic intervention in order to reach B-cell depletion are subject to discussion in present article. Here we describe a clin...

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Autores principales:	E. P. Evdoshenko, A. L. Maslyancky, L. G. Zaslavsky, A. A. Skoromets, I. S. Ziuzgin, O. E. Riabykina, N. A. Totolian, E. E. Zueva, S. V. Lapin, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	b-cells multiple sclerosis rituximab mitozantrone Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e32cdf8316b547858a675cbad0056b07
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spelling	oai:doaj.org-article:e32cdf8316b547858a675cbad0056b072021-11-18T08:03:38ZOPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS1563-06252313-741X10.15789/1563-0625-2009-1-63-70https://doaj.org/article/e32cdf8316b547858a675cbad0056b072014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/144https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A new role of B-cells in pathogenesis of multiple sclerosis (MS), their relations with B-cells indevelopment of inflammation and probable mechanisms of advanced therapeutic intervention in order to reach B-cell depletion are subject to discussion in present article. Here we describe a clinical case of MS with a resistant clinical course, and results of anti B-cell treatment. To attain maximal clinical effect, a novel therapeutic regimen (a combination of rituximab and mitozantrone) was applied. Clinical, radiological and laboratory methods were used to substantiate the efficiency of treatment.E. P. EvdoshenkoA. L. MaslyanckyL. G. ZaslavskyA. A. SkorometsI. S. ZiuzginO. E. RiabykinaN. A. TotolianE. E. ZuevaS. V. LapinAreg A. TotolianSPb RAACIarticleb-cellsmultiple sclerosisrituximabmitozantroneImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 1, Pp 63-70 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	b-cells multiple sclerosis rituximab mitozantrone Immunologic diseases. Allergy RC581-607
spellingShingle	b-cells multiple sclerosis rituximab mitozantrone Immunologic diseases. Allergy RC581-607 E. P. Evdoshenko A. L. Maslyancky L. G. Zaslavsky A. A. Skoromets I. S. Ziuzgin O. E. Riabykina N. A. Totolian E. E. Zueva S. V. Lapin Areg A. Totolian OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS
description	Abstract. A new role of B-cells in pathogenesis of multiple sclerosis (MS), their relations with B-cells indevelopment of inflammation and probable mechanisms of advanced therapeutic intervention in order to reach B-cell depletion are subject to discussion in present article. Here we describe a clinical case of MS with a resistant clinical course, and results of anti B-cell treatment. To attain maximal clinical effect, a novel therapeutic regimen (a combination of rituximab and mitozantrone) was applied. Clinical, radiological and laboratory methods were used to substantiate the efficiency of treatment.
format	article
author	E. P. Evdoshenko A. L. Maslyancky L. G. Zaslavsky A. A. Skoromets I. S. Ziuzgin O. E. Riabykina N. A. Totolian E. E. Zueva S. V. Lapin Areg A. Totolian
author_facet	E. P. Evdoshenko A. L. Maslyancky L. G. Zaslavsky A. A. Skoromets I. S. Ziuzgin O. E. Riabykina N. A. Totolian E. E. Zueva S. V. Lapin Areg A. Totolian
author_sort	E. P. Evdoshenko
title	OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS
title_short	OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS
title_full	OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS
title_fullStr	OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS
title_full_unstemmed	OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS
title_sort	opportunities of anti b-cell therapy in multiple sclerosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/e32cdf8316b547858a675cbad0056b07
work_keys_str_mv	AT epevdoshenko opportunitiesofantibcelltherapyinmultiplesclerosis AT almaslyancky opportunitiesofantibcelltherapyinmultiplesclerosis AT lgzaslavsky opportunitiesofantibcelltherapyinmultiplesclerosis AT aaskoromets opportunitiesofantibcelltherapyinmultiplesclerosis AT isziuzgin opportunitiesofantibcelltherapyinmultiplesclerosis AT oeriabykina opportunitiesofantibcelltherapyinmultiplesclerosis AT natotolian opportunitiesofantibcelltherapyinmultiplesclerosis AT eezueva opportunitiesofantibcelltherapyinmultiplesclerosis AT svlapin opportunitiesofantibcelltherapyinmultiplesclerosis AT aregatotolian opportunitiesofantibcelltherapyinmultiplesclerosis
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OPPORTUNITIES OF ANTI B-CELL THERAPY IN MULTIPLE SCLEROSIS

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