Lymph node ratio as a predictor for minor salivary gland cancer in head and neck

Abstract Background We investigate whether pathological continuous variables of lymph nodes were related with survival results of carcinomas of minor salivary gland carcinoma in head and neck. Methods Forty-four cases with minor salivary gland carcinoma who underwent both primary resection and neck...

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Autores principales:	Hidenori Suzuki, Eiichi Sasaki, Gaku Takano, Seiya Goto, Daisuke Nishikawa, Shintaro Beppu, Hoshino Terada, Michi Sawabe, Nobuhiro Hanai
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Lymph node ratio Log odds of positive lymph nodes Overall survival Minor salivary gland carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e32daa7d41b7412c9c411fbb9d1e68b6
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spelling	oai:doaj.org-article:e32daa7d41b7412c9c411fbb9d1e68b62021-11-08T11:01:55ZLymph node ratio as a predictor for minor salivary gland cancer in head and neck10.1186/s12885-021-08877-31471-2407https://doaj.org/article/e32daa7d41b7412c9c411fbb9d1e68b62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08877-3https://doaj.org/toc/1471-2407Abstract Background We investigate whether pathological continuous variables of lymph nodes were related with survival results of carcinomas of minor salivary gland carcinoma in head and neck. Methods Forty-four cases with minor salivary gland carcinoma who underwent both primary resection and neck dissection were retrospectively enrolled. The pathological continuous variables were evaluated by the number of positive lymph nodes, lymph node ratio, and log odds of positive lymph nodes. Receiver operating curve analysis was used for the cut-off values of the carcinoma-specific death. Log-rank test and Cox’s proportional hazards model were used for uni−/multi-variate survival analyses adjusting for pathological stage, respectively. Results Lymph node ratio = 0.05 as well as log odds of positive lymph nodes = − 2.73 predicted the carcinoma-specific death. Both lymph node ratio and log odds of positive lymph nodes were significantly related with survival outcomes by the univariate analysis. Lymph node ratio ≥ 0.05 was associated with shorter disease-specific (hazard ratio = 7.90, 95% confidence interval = 1.54–57.1), disease-free (hazard ratio = 4.15, 95% confidence interval = 1.48–11.2) and overall (hazard ratio = 4.84, 95% confidence interval = 1.05–24.8) survival in the multivariate analysis. Conclusion A higher lymph node ratio of minor salivary gland carcinoma is a predictor of shorter survival results.Hidenori SuzukiEiichi SasakiGaku TakanoSeiya GotoDaisuke NishikawaShintaro BeppuHoshino TeradaMichi SawabeNobuhiro HanaiBMCarticleLymph node ratioLog odds of positive lymph nodesOverall survivalMinor salivary gland carcinomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lymph node ratio Log odds of positive lymph nodes Overall survival Minor salivary gland carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Lymph node ratio Log odds of positive lymph nodes Overall survival Minor salivary gland carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hidenori Suzuki Eiichi Sasaki Gaku Takano Seiya Goto Daisuke Nishikawa Shintaro Beppu Hoshino Terada Michi Sawabe Nobuhiro Hanai Lymph node ratio as a predictor for minor salivary gland cancer in head and neck
description	Abstract Background We investigate whether pathological continuous variables of lymph nodes were related with survival results of carcinomas of minor salivary gland carcinoma in head and neck. Methods Forty-four cases with minor salivary gland carcinoma who underwent both primary resection and neck dissection were retrospectively enrolled. The pathological continuous variables were evaluated by the number of positive lymph nodes, lymph node ratio, and log odds of positive lymph nodes. Receiver operating curve analysis was used for the cut-off values of the carcinoma-specific death. Log-rank test and Cox’s proportional hazards model were used for uni−/multi-variate survival analyses adjusting for pathological stage, respectively. Results Lymph node ratio = 0.05 as well as log odds of positive lymph nodes = − 2.73 predicted the carcinoma-specific death. Both lymph node ratio and log odds of positive lymph nodes were significantly related with survival outcomes by the univariate analysis. Lymph node ratio ≥ 0.05 was associated with shorter disease-specific (hazard ratio = 7.90, 95% confidence interval = 1.54–57.1), disease-free (hazard ratio = 4.15, 95% confidence interval = 1.48–11.2) and overall (hazard ratio = 4.84, 95% confidence interval = 1.05–24.8) survival in the multivariate analysis. Conclusion A higher lymph node ratio of minor salivary gland carcinoma is a predictor of shorter survival results.
format	article
author	Hidenori Suzuki Eiichi Sasaki Gaku Takano Seiya Goto Daisuke Nishikawa Shintaro Beppu Hoshino Terada Michi Sawabe Nobuhiro Hanai
author_facet	Hidenori Suzuki Eiichi Sasaki Gaku Takano Seiya Goto Daisuke Nishikawa Shintaro Beppu Hoshino Terada Michi Sawabe Nobuhiro Hanai
author_sort	Hidenori Suzuki
title	Lymph node ratio as a predictor for minor salivary gland cancer in head and neck
title_short	Lymph node ratio as a predictor for minor salivary gland cancer in head and neck
title_full	Lymph node ratio as a predictor for minor salivary gland cancer in head and neck
title_fullStr	Lymph node ratio as a predictor for minor salivary gland cancer in head and neck
title_full_unstemmed	Lymph node ratio as a predictor for minor salivary gland cancer in head and neck
title_sort	lymph node ratio as a predictor for minor salivary gland cancer in head and neck
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e32daa7d41b7412c9c411fbb9d1e68b6
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Lymph node ratio as a predictor for minor salivary gland cancer in head and neck

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