Biological process activity transformation of single cell gene expression for cross-species alignment

Single cell RNA-Seq data can report on cellular types and states, but low signal-to noise and sparse data can make interpretation of cellular state difficult. Here the authors propose a transformation strategy to map RNA-Seq data to biological process activities that are species-agnostic and allow f...

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Auteurs principaux:	Hongxu Ding, Andrew Blair, Ying Yang, Joshua M. Stuart
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e32e60d474f14311b3573e25cb1cad5f
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id	oai:doaj.org-article:e32e60d474f14311b3573e25cb1cad5f
record_format	dspace
spelling	oai:doaj.org-article:e32e60d474f14311b3573e25cb1cad5f2021-12-02T14:38:43ZBiological process activity transformation of single cell gene expression for cross-species alignment10.1038/s41467-019-12924-w2041-1723https://doaj.org/article/e32e60d474f14311b3573e25cb1cad5f2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12924-whttps://doaj.org/toc/2041-1723Single cell RNA-Seq data can report on cellular types and states, but low signal-to noise and sparse data can make interpretation of cellular state difficult. Here the authors propose a transformation strategy to map RNA-Seq data to biological process activities that are species-agnostic and allow for comparison across species.Hongxu DingAndrew BlairYing YangJoshua M. StuartNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongxu Ding Andrew Blair Ying Yang Joshua M. Stuart Biological process activity transformation of single cell gene expression for cross-species alignment
description	Single cell RNA-Seq data can report on cellular types and states, but low signal-to noise and sparse data can make interpretation of cellular state difficult. Here the authors propose a transformation strategy to map RNA-Seq data to biological process activities that are species-agnostic and allow for comparison across species.
format	article
author	Hongxu Ding Andrew Blair Ying Yang Joshua M. Stuart
author_facet	Hongxu Ding Andrew Blair Ying Yang Joshua M. Stuart
author_sort	Hongxu Ding
title	Biological process activity transformation of single cell gene expression for cross-species alignment
title_short	Biological process activity transformation of single cell gene expression for cross-species alignment
title_full	Biological process activity transformation of single cell gene expression for cross-species alignment
title_fullStr	Biological process activity transformation of single cell gene expression for cross-species alignment
title_full_unstemmed	Biological process activity transformation of single cell gene expression for cross-species alignment
title_sort	biological process activity transformation of single cell gene expression for cross-species alignment
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e32e60d474f14311b3573e25cb1cad5f
work_keys_str_mv	AT hongxuding biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment AT andrewblair biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment AT yingyang biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment AT joshuamstuart biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment
_version_	1718390925802078208

Biological process activity transformation of single cell gene expression for cross-species alignment

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