Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines

Katarzyna Niemirowicz-Laskowska,1 Katarzyna Głuszek,1 Ewelina Piktel,1 Karlis Pajuste,2 Bonita Durnaś,3 Grzegorz Król,3 Agnieszka Z Wilczewska,4 Paul A Janmey,5 Aiva Plotniece,2 Robert Bucki1 1Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok,...

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Autores principales:	Niemirowicz-Laskowska K, Głuszek K, Piktel E, Pajuste K, Durnaś B, Król G, Wilczewska AZ, Janmey PA, Plotniece A, Bucki R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	magnetic nanoparticles 1 4-dihydropyridine antibacterial antifungal immunomodulatory properties Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e32e7d4c62804fc99358142898c368ef
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spelling	oai:doaj.org-article:e32e7d4c62804fc99358142898c368ef2021-12-02T00:53:57ZBactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines1178-2013https://doaj.org/article/e32e7d4c62804fc99358142898c368ef2018-06-01T00:00:00Zhttps://www.dovepress.com/bactericidal-and-immunomodulatory-properties-of-magnetic-nanoparticles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Katarzyna Niemirowicz-Laskowska,1 Katarzyna Głuszek,1 Ewelina Piktel,1 Karlis Pajuste,2 Bonita Durnaś,3 Grzegorz Król,3 Agnieszka Z Wilczewska,4 Paul A Janmey,5 Aiva Plotniece,2 Robert Bucki1 1Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, Poland; 2Laboratory of Membrane Active Compounds and β-Diketones, Latvian Institute of Organic Synthesis, Riga, Latvia; 3Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Kielce, 4Institute of Chemistry, University of Bialystok, Białystok, Poland; 5Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA Background: 1,4-Dihydropyridine (1,4-DHP) and its derivatives are well-known calcium channel blockers with antiarrhythmic and antihypertensive activities. These compounds exhibit pleiotropic effects including antimicrobial activities that rely on their positive charge and amphipathic nature. Use of magnetic nanoparticles (MNPs) as carriers of 1,4-DHP modulates their properties and enables improved formulations with higher efficacy and less toxicity. Methods: In this study, the antimicrobial and immunomodulatory activities of novel 1,4-DHP derivatives in free form and immobilized on MNPs were determined by evaluating pathogen outgrowth and proinflammatory cytokine release in experimental settings that involve incubation of various 1,4-DHPs with clinical isolates of bacteria or fungi as well as mammalian cell culture models. Results: Conventional immobilization of 1,4-DHP on aminosilane-coated MNPs markedly enhances their antimicrobial activity compared to nonimmobilized molecules, in part because of the higher affinity of these nanosystems for bacterial cell wall components in the presence of human body fluids. Conclusion: Optimized nanosystems are characterized by improved biocompatibility and higher anti-inflammatory properties that provide new opportunities for the therapy of infectious diseases. Keywords: magnetic nanoparticles, 1,4-dihydropyridine, antibacterial, antifungal, immunomodulatory propertiesNiemirowicz-Laskowska KGłuszek KPiktel EPajuste KDurnaś BKról GWilczewska AZJanmey PAPlotniece ABucki RDove Medical Pressarticlemagnetic nanoparticles14-dihydropyridineantibacterialantifungalimmunomodulatory propertiesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3411-3424 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic nanoparticles 1 4-dihydropyridine antibacterial antifungal immunomodulatory properties Medicine (General) R5-920
spellingShingle	magnetic nanoparticles 1 4-dihydropyridine antibacterial antifungal immunomodulatory properties Medicine (General) R5-920 Niemirowicz-Laskowska K Głuszek K Piktel E Pajuste K Durnaś B Król G Wilczewska AZ Janmey PA Plotniece A Bucki R Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
description	Katarzyna Niemirowicz-Laskowska,1 Katarzyna Głuszek,1 Ewelina Piktel,1 Karlis Pajuste,2 Bonita Durnaś,3 Grzegorz Król,3 Agnieszka Z Wilczewska,4 Paul A Janmey,5 Aiva Plotniece,2 Robert Bucki1 1Department of Microbiological and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, Poland; 2Laboratory of Membrane Active Compounds and β-Diketones, Latvian Institute of Organic Synthesis, Riga, Latvia; 3Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Kielce, 4Institute of Chemistry, University of Bialystok, Białystok, Poland; 5Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA Background: 1,4-Dihydropyridine (1,4-DHP) and its derivatives are well-known calcium channel blockers with antiarrhythmic and antihypertensive activities. These compounds exhibit pleiotropic effects including antimicrobial activities that rely on their positive charge and amphipathic nature. Use of magnetic nanoparticles (MNPs) as carriers of 1,4-DHP modulates their properties and enables improved formulations with higher efficacy and less toxicity. Methods: In this study, the antimicrobial and immunomodulatory activities of novel 1,4-DHP derivatives in free form and immobilized on MNPs were determined by evaluating pathogen outgrowth and proinflammatory cytokine release in experimental settings that involve incubation of various 1,4-DHPs with clinical isolates of bacteria or fungi as well as mammalian cell culture models. Results: Conventional immobilization of 1,4-DHP on aminosilane-coated MNPs markedly enhances their antimicrobial activity compared to nonimmobilized molecules, in part because of the higher affinity of these nanosystems for bacterial cell wall components in the presence of human body fluids. Conclusion: Optimized nanosystems are characterized by improved biocompatibility and higher anti-inflammatory properties that provide new opportunities for the therapy of infectious diseases. Keywords: magnetic nanoparticles, 1,4-dihydropyridine, antibacterial, antifungal, immunomodulatory properties
format	article
author	Niemirowicz-Laskowska K Głuszek K Piktel E Pajuste K Durnaś B Król G Wilczewska AZ Janmey PA Plotniece A Bucki R
author_facet	Niemirowicz-Laskowska K Głuszek K Piktel E Pajuste K Durnaś B Król G Wilczewska AZ Janmey PA Plotniece A Bucki R
author_sort	Niemirowicz-Laskowska K
title	Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
title_short	Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
title_full	Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
title_fullStr	Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
title_full_unstemmed	Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
title_sort	bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e32e7d4c62804fc99358142898c368ef
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Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines

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