BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

Blocking B-cell activating factor (BAFF), an important soluble factor for B-cell responses, with specific antibodies is approved for treating autoimmune disorders. Here the authors show, with structural data, that antibody-BAFF interactions not only interrupt BAFF–receptor-binding, but also induce t...

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Autores principales: Woori Shin, Hyun Tae Lee, Heejin Lim, Sang Hyung Lee, Ji Young Son, Jee Un Lee, Ki-Young Yoo, Seong Eon Ryu, Jaejun Rhie, Ju Yeon Lee, Yong-Seok Heo
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e330576c14f6477d992a74d39ff8392f
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spelling oai:doaj.org-article:e330576c14f6477d992a74d39ff8392f2021-12-02T16:56:54ZBAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus10.1038/s41467-018-03620-22041-1723https://doaj.org/article/e330576c14f6477d992a74d39ff8392f2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03620-2https://doaj.org/toc/2041-1723Blocking B-cell activating factor (BAFF), an important soluble factor for B-cell responses, with specific antibodies is approved for treating autoimmune disorders. Here the authors show, with structural data, that antibody-BAFF interactions not only interrupt BAFF–receptor-binding, but also induce the formation of a less active BAFF polymer.Woori ShinHyun Tae LeeHeejin LimSang Hyung LeeJi Young SonJee Un LeeKi-Young YooSeong Eon RyuJaejun RhieJu Yeon LeeYong-Seok HeoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Woori Shin
Hyun Tae Lee
Heejin Lim
Sang Hyung Lee
Ji Young Son
Jee Un Lee
Ki-Young Yoo
Seong Eon Ryu
Jaejun Rhie
Ju Yeon Lee
Yong-Seok Heo
BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus
description Blocking B-cell activating factor (BAFF), an important soluble factor for B-cell responses, with specific antibodies is approved for treating autoimmune disorders. Here the authors show, with structural data, that antibody-BAFF interactions not only interrupt BAFF–receptor-binding, but also induce the formation of a less active BAFF polymer.
format article
author Woori Shin
Hyun Tae Lee
Heejin Lim
Sang Hyung Lee
Ji Young Son
Jee Un Lee
Ki-Young Yoo
Seong Eon Ryu
Jaejun Rhie
Ju Yeon Lee
Yong-Seok Heo
author_facet Woori Shin
Hyun Tae Lee
Heejin Lim
Sang Hyung Lee
Ji Young Son
Jee Un Lee
Ki-Young Yoo
Seong Eon Ryu
Jaejun Rhie
Ju Yeon Lee
Yong-Seok Heo
author_sort Woori Shin
title BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus
title_short BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus
title_full BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus
title_fullStr BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus
title_full_unstemmed BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus
title_sort baff-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e330576c14f6477d992a74d39ff8392f
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