Association between Equol Production Status and Nonalcoholic Steatohepatitis

Equol is a metabolite of daidzein, a major soybean isoflavone with estrogenic and antioxidant activities. As the production of equol depends on the presence of certain members of the intestinal microflora, not all individuals can produce equol. We examined the relationship between NASH histological...

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Autores principales:	Takemi Akahane, Daisuke Kaya, Ryuichi Noguchi, Kosuke Kaji, Haruna Miyakawa, Yukihisa Fujinaga, Yuki Tsuji, Hiroaki Takaya, Yasuhiko Sawada, Masanori Furukawa, Koh Kitagawa, Takahiro Ozutsumi, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Hitoshi Yoshiji
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	equol nonalcoholic steatohepatitis estrogen menopause Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e33b1dba27d64357b7250887b7a5adcb
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spelling	oai:doaj.org-article:e33b1dba27d64357b7250887b7a5adcb2021-11-11T17:19:07ZAssociation between Equol Production Status and Nonalcoholic Steatohepatitis10.3390/ijms2221119041422-00671661-6596https://doaj.org/article/e33b1dba27d64357b7250887b7a5adcb2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11904https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Equol is a metabolite of daidzein, a major soybean isoflavone with estrogenic and antioxidant activities. As the production of equol depends on the presence of certain members of the intestinal microflora, not all individuals can produce equol. We examined the relationship between NASH histological features and equol production. In an animal model, obese OLETF rats were intraperitoneally injected with a porcine serum to augment liver fibrogenesis. Equol-rich soy product, SE5-OH was orally administered during the experimental period. Treatment with SE5-OH markedly attenuated the development of liver fibrosis and expression of alpha-smooth muscle actin. In clinical research, 38 NAFLD patients (13 men and 25 women) were included. The degree of fibrosis and ballooning in equol-nonproducers was significantly higher than in equol-producers in women. The percentage of nonproducers with NAFLD activity score (NAS) ≥ 5 was significantly higher than that of producers. None of the histological features were significantly different between nonproducers and producers in men. Decision tree analysis identified predictors for NAS ≥ 5 in women. The status of equol production was the strongest predictor, followed by fasting glucose. Since equol can be noninvasively detected in urine, it can be applied as a screening tool for the progression of NASH in women.Takemi AkahaneDaisuke KayaRyuichi NoguchiKosuke KajiHaruna MiyakawaYukihisa FujinagaYuki TsujiHiroaki TakayaYasuhiko SawadaMasanori FurukawaKoh KitagawaTakahiro OzutsumiHideto KawarataniKei MoriyaTadashi NamisakiHitoshi YoshijiMDPI AGarticleequolnonalcoholic steatohepatitisestrogenmenopauseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11904, p 11904 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	equol nonalcoholic steatohepatitis estrogen menopause Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	equol nonalcoholic steatohepatitis estrogen menopause Biology (General) QH301-705.5 Chemistry QD1-999 Takemi Akahane Daisuke Kaya Ryuichi Noguchi Kosuke Kaji Haruna Miyakawa Yukihisa Fujinaga Yuki Tsuji Hiroaki Takaya Yasuhiko Sawada Masanori Furukawa Koh Kitagawa Takahiro Ozutsumi Hideto Kawaratani Kei Moriya Tadashi Namisaki Hitoshi Yoshiji Association between Equol Production Status and Nonalcoholic Steatohepatitis
description	Equol is a metabolite of daidzein, a major soybean isoflavone with estrogenic and antioxidant activities. As the production of equol depends on the presence of certain members of the intestinal microflora, not all individuals can produce equol. We examined the relationship between NASH histological features and equol production. In an animal model, obese OLETF rats were intraperitoneally injected with a porcine serum to augment liver fibrogenesis. Equol-rich soy product, SE5-OH was orally administered during the experimental period. Treatment with SE5-OH markedly attenuated the development of liver fibrosis and expression of alpha-smooth muscle actin. In clinical research, 38 NAFLD patients (13 men and 25 women) were included. The degree of fibrosis and ballooning in equol-nonproducers was significantly higher than in equol-producers in women. The percentage of nonproducers with NAFLD activity score (NAS) ≥ 5 was significantly higher than that of producers. None of the histological features were significantly different between nonproducers and producers in men. Decision tree analysis identified predictors for NAS ≥ 5 in women. The status of equol production was the strongest predictor, followed by fasting glucose. Since equol can be noninvasively detected in urine, it can be applied as a screening tool for the progression of NASH in women.
format	article
author	Takemi Akahane Daisuke Kaya Ryuichi Noguchi Kosuke Kaji Haruna Miyakawa Yukihisa Fujinaga Yuki Tsuji Hiroaki Takaya Yasuhiko Sawada Masanori Furukawa Koh Kitagawa Takahiro Ozutsumi Hideto Kawaratani Kei Moriya Tadashi Namisaki Hitoshi Yoshiji
author_facet	Takemi Akahane Daisuke Kaya Ryuichi Noguchi Kosuke Kaji Haruna Miyakawa Yukihisa Fujinaga Yuki Tsuji Hiroaki Takaya Yasuhiko Sawada Masanori Furukawa Koh Kitagawa Takahiro Ozutsumi Hideto Kawaratani Kei Moriya Tadashi Namisaki Hitoshi Yoshiji
author_sort	Takemi Akahane
title	Association between Equol Production Status and Nonalcoholic Steatohepatitis
title_short	Association between Equol Production Status and Nonalcoholic Steatohepatitis
title_full	Association between Equol Production Status and Nonalcoholic Steatohepatitis
title_fullStr	Association between Equol Production Status and Nonalcoholic Steatohepatitis
title_full_unstemmed	Association between Equol Production Status and Nonalcoholic Steatohepatitis
title_sort	association between equol production status and nonalcoholic steatohepatitis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e33b1dba27d64357b7250887b7a5adcb
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_version_	1718432150064201728

Association between Equol Production Status and Nonalcoholic Steatohepatitis

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