Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism.

Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism.

Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor (BDNF) is key synaptogenic molecule and targeting synaptic repair through modulation of BDNF signalling has been suggested as a potential drug...

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Main Authors: Fruzsina Soltész, John Suckling, Phil Lawrence, Roger Tait, Cinly Ooi, Graham Bentley, Chris M Dodds, Sam R Miller, David R Wille, Misha Byrne, Simon M McHugh, Mark A Bellgrove, Rodney J Croft, Bai Lu, Edward T Bullmore, Pradeep J Nathan
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/e33d779d8d374051b26737b203aa60e3
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https://doaj.org/article/e33d779d8d374051b26737b203aa60e3

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