Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films

Drug-eluting stents implanted in blood vessels are subject to various dynamics of blood flow. In this study, we present the evaluation of a mathematical model considering the effect of flow rate, to simulate the kinetic profiles of drug release (Diclofenac Sodium (DS)) from in-vitro from PLGA films....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abbasnezhad Navideh, Bakir Farid, Champmartin Stéphane, Shirinbayan Mohammadali
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/e33eaa423a2444c3ab49f3413d5156c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e33eaa423a2444c3ab49f3413d5156c9
record_format	dspace
spelling	oai:doaj.org-article:e33eaa423a2444c3ab49f3413d5156c92021-11-12T11:44:34ZAssessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films2267-124210.1051/e3sconf/202132104011https://doaj.org/article/e33eaa423a2444c3ab49f3413d5156c92021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/97/e3sconf_icchmt2021_04011.pdfhttps://doaj.org/toc/2267-1242Drug-eluting stents implanted in blood vessels are subject to various dynamics of blood flow. In this study, we present the evaluation of a mathematical model considering the effect of flow rate, to simulate the kinetic profiles of drug release (Diclofenac Sodium (DS)) from in-vitro from PLGA films. This model solves a set of non-linear equation for modeling simultaneously the burst, diffusion, swelling and erosion involved in the mechanisms of liberation. The release parameters depending on the flow rate are determined using the corresponding mathematical equations. For the evaluation of the proposed model, test data obtained in our laboratory are used. To quantify DS release from drug-carrier PLGA films, we used the flow-through cell apparatus in a closed-loop. Four flow rate values are applied. For each value, the model-substance liberation kinetics showed an increase in drug released with the flow rate. The simulated release profiles show good agreement with the experimental results. Therefore, the use of this model could provide a practical tool to assess in-vitro drug release profiles from polymer matrices under continuous flow rate constraint, and could help improve the design of drug eluting stents.Abbasnezhad NavidehBakir FaridChampmartin StéphaneShirinbayan MohammadaliEDP SciencesarticleEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 321, p 04011 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Environmental sciences GE1-350
spellingShingle	Environmental sciences GE1-350 Abbasnezhad Navideh Bakir Farid Champmartin Stéphane Shirinbayan Mohammadali Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films
description	Drug-eluting stents implanted in blood vessels are subject to various dynamics of blood flow. In this study, we present the evaluation of a mathematical model considering the effect of flow rate, to simulate the kinetic profiles of drug release (Diclofenac Sodium (DS)) from in-vitro from PLGA films. This model solves a set of non-linear equation for modeling simultaneously the burst, diffusion, swelling and erosion involved in the mechanisms of liberation. The release parameters depending on the flow rate are determined using the corresponding mathematical equations. For the evaluation of the proposed model, test data obtained in our laboratory are used. To quantify DS release from drug-carrier PLGA films, we used the flow-through cell apparatus in a closed-loop. Four flow rate values are applied. For each value, the model-substance liberation kinetics showed an increase in drug released with the flow rate. The simulated release profiles show good agreement with the experimental results. Therefore, the use of this model could provide a practical tool to assess in-vitro drug release profiles from polymer matrices under continuous flow rate constraint, and could help improve the design of drug eluting stents.
format	article
author	Abbasnezhad Navideh Bakir Farid Champmartin Stéphane Shirinbayan Mohammadali
author_facet	Abbasnezhad Navideh Bakir Farid Champmartin Stéphane Shirinbayan Mohammadali
author_sort	Abbasnezhad Navideh
title	Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films
title_short	Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films
title_full	Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films
title_fullStr	Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films
title_full_unstemmed	Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films
title_sort	assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from plga films
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/e33eaa423a2444c3ab49f3413d5156c9
work_keys_str_mv	AT abbasnezhadnavideh assessmentofamathematicalmodelconsideringtheeffectofflowrateoninvitrodrugreleasefromplgafilms AT bakirfarid assessmentofamathematicalmodelconsideringtheeffectofflowrateoninvitrodrugreleasefromplgafilms AT champmartinstephane assessmentofamathematicalmodelconsideringtheeffectofflowrateoninvitrodrugreleasefromplgafilms AT shirinbayanmohammadali assessmentofamathematicalmodelconsideringtheeffectofflowrateoninvitrodrugreleasefromplgafilms
_version_	1718430587221442560

Assessment of a mathematical model considering the effect of flow rate on in-vitro drug-release from PLGA films

Ejemplares similares