The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Nandeeta Samad,1 Temitayo Eniola Sodunke,2 Abdullahi Rabiu Abubakar,3 Iffat Jahan,4 Paras Sharma,5 Salequl Islam,6 Siddhartha Dutta,7 Mainul Haque8 1Department of Public Health, North South University, Dhaka, 1229, Bangladesh; 2Department of Anatomy, University of Ilorin, Ilorin, Kwara State, Nigeri...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samad N, Sodunke TE, Abubakar AR, Jahan I, Sharma P, Islam S, Dutta S, Haque M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	zinc therapy microelement immune-boosting efficacy covid-19 viral infections pneumonia pandemic. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e3429a347b3246739d9742c13d648c06
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e3429a347b3246739d9742c13d648c06
record_format	dspace
spelling	oai:doaj.org-article:e3429a347b3246739d9742c13d648c062021-12-02T10:35:46ZThe Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic1178-7031https://doaj.org/article/e3429a347b3246739d9742c13d648c062021-02-01T00:00:00Zhttps://www.dovepress.com/the-implications-of-zinc-therapy-in-combating-the-covid-19-global-pand-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Nandeeta Samad,1 Temitayo Eniola Sodunke,2 Abdullahi Rabiu Abubakar,3 Iffat Jahan,4 Paras Sharma,5 Salequl Islam,6 Siddhartha Dutta,7 Mainul Haque8 1Department of Public Health, North South University, Dhaka, 1229, Bangladesh; 2Department of Anatomy, University of Ilorin, Ilorin, Kwara State, Nigeria; 3Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Bayero University, Kano, 700233, Nigeria; 4Department of Physiology, Eastern Medical College, Cumilla, Bangladesh; 5Department of Pharmacognosy, BVM College of Pharmacy, Gwalior, India; 6Department of Microbiology, Jahangirnagar University, Dhaka, 1342, Bangladesh; 7Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India; 8The Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kuala Lumpur, MalaysiaCorrespondence: Mainul HaqueUnit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, Kuala Lumpur, 57000, MalaysiaTel +60 10 926 5543Email runurono@gmail.comAbstract: The global pandemic from COVID-19 infection has generated significant public health concerns, both health-wise and economically. There is no specific pharmacological antiviral therapeutic option to date available for COVID-19 management. Also, there is an urgent need to discover effective medicines, prevention, and control methods because of the harsh death toll from this novel coronavirus infection. Acute respiratory tract infections, significantly lower respiratory tract infections, and pneumonia are the primary cause of millions of deaths worldwide. The role of micronutrients, including trace elements, boosted the human immune system and was well established. Several vitamins such as vitamin A, B6, B12, C, D, E, and folate; microelement including zinc, iron, selenium, magnesium, and copper; omega-3 fatty acids as eicosapentaenoic acid and docosahexaenoic acid plays essential physiological roles in promoting the immune system. Furthermore, zinc is an indispensable microelement essential for a thorough enzymatic physiological process. It also helps regulate gene-transcription such as DNA replication, RNA transcription, cell division, and cell activation in the human biological system. Subsequently, zinc, together with natural scavenger cells and neutrophils, are also involved in developing cells responsible for regulating nonspecific immunity. The modern food habit often promotes zinc deficiency; as such, quite a few COVID-19 patients presented to hospitals were frequently diagnosed as zinc deficient. Earlier studies documented that zinc deficiency predisposes patients to a viral infection such as herpes simplex, common cold, hepatitis C, severe acute respiratory syndrome coronavirus (SARS-CoV-1), the human immunodeficiency virus (HIV) because of reducing antiviral immunity. This manuscript aimed to discuss the various roles played by zinc in the management of COVID-19 infection.Keywords: zinc therapy, microelement, immune-boosting, efficacy, COVID-19, viral infections, pneumonia, pandemicSamad NSodunke TEAbubakar ARJahan ISharma PIslam SDutta SHaque MDove Medical Pressarticlezinc therapymicroelementimmune-boostingefficacycovid-19viral infectionspneumoniapandemic.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 527-550 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	zinc therapy microelement immune-boosting efficacy covid-19 viral infections pneumonia pandemic. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	zinc therapy microelement immune-boosting efficacy covid-19 viral infections pneumonia pandemic. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Samad N Sodunke TE Abubakar AR Jahan I Sharma P Islam S Dutta S Haque M The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
description	Nandeeta Samad,1 Temitayo Eniola Sodunke,2 Abdullahi Rabiu Abubakar,3 Iffat Jahan,4 Paras Sharma,5 Salequl Islam,6 Siddhartha Dutta,7 Mainul Haque8 1Department of Public Health, North South University, Dhaka, 1229, Bangladesh; 2Department of Anatomy, University of Ilorin, Ilorin, Kwara State, Nigeria; 3Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Bayero University, Kano, 700233, Nigeria; 4Department of Physiology, Eastern Medical College, Cumilla, Bangladesh; 5Department of Pharmacognosy, BVM College of Pharmacy, Gwalior, India; 6Department of Microbiology, Jahangirnagar University, Dhaka, 1342, Bangladesh; 7Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India; 8The Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kuala Lumpur, MalaysiaCorrespondence: Mainul HaqueUnit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Perdana Sungai Besi, Kuala Lumpur, 57000, MalaysiaTel +60 10 926 5543Email runurono@gmail.comAbstract: The global pandemic from COVID-19 infection has generated significant public health concerns, both health-wise and economically. There is no specific pharmacological antiviral therapeutic option to date available for COVID-19 management. Also, there is an urgent need to discover effective medicines, prevention, and control methods because of the harsh death toll from this novel coronavirus infection. Acute respiratory tract infections, significantly lower respiratory tract infections, and pneumonia are the primary cause of millions of deaths worldwide. The role of micronutrients, including trace elements, boosted the human immune system and was well established. Several vitamins such as vitamin A, B6, B12, C, D, E, and folate; microelement including zinc, iron, selenium, magnesium, and copper; omega-3 fatty acids as eicosapentaenoic acid and docosahexaenoic acid plays essential physiological roles in promoting the immune system. Furthermore, zinc is an indispensable microelement essential for a thorough enzymatic physiological process. It also helps regulate gene-transcription such as DNA replication, RNA transcription, cell division, and cell activation in the human biological system. Subsequently, zinc, together with natural scavenger cells and neutrophils, are also involved in developing cells responsible for regulating nonspecific immunity. The modern food habit often promotes zinc deficiency; as such, quite a few COVID-19 patients presented to hospitals were frequently diagnosed as zinc deficient. Earlier studies documented that zinc deficiency predisposes patients to a viral infection such as herpes simplex, common cold, hepatitis C, severe acute respiratory syndrome coronavirus (SARS-CoV-1), the human immunodeficiency virus (HIV) because of reducing antiviral immunity. This manuscript aimed to discuss the various roles played by zinc in the management of COVID-19 infection.Keywords: zinc therapy, microelement, immune-boosting, efficacy, COVID-19, viral infections, pneumonia, pandemic
format	article
author	Samad N Sodunke TE Abubakar AR Jahan I Sharma P Islam S Dutta S Haque M
author_facet	Samad N Sodunke TE Abubakar AR Jahan I Sharma P Islam S Dutta S Haque M
author_sort	Samad N
title	The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
title_short	The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
title_full	The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
title_fullStr	The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
title_full_unstemmed	The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
title_sort	implications of zinc therapy in combating the covid-19 global pandemic
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e3429a347b3246739d9742c13d648c06
work_keys_str_mv	AT samadn theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT sodunkete theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT abubakarar theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT jahani theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT sharmap theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT islams theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT duttas theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT haquem theimplicationsofzinctherapyincombatingthecovid19globalpandemic AT samadn implicationsofzinctherapyincombatingthecovid19globalpandemic AT sodunkete implicationsofzinctherapyincombatingthecovid19globalpandemic AT abubakarar implicationsofzinctherapyincombatingthecovid19globalpandemic AT jahani implicationsofzinctherapyincombatingthecovid19globalpandemic AT sharmap implicationsofzinctherapyincombatingthecovid19globalpandemic AT islams implicationsofzinctherapyincombatingthecovid19globalpandemic AT duttas implicationsofzinctherapyincombatingthecovid19globalpandemic AT haquem implicationsofzinctherapyincombatingthecovid19globalpandemic
_version_	1718397034113794048

The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Ejemplares similares